Yearly Archives: 2026

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Upper-Body Versus Femoral Return in Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-analysis

Abstract Upper-body peripheral arterial return is used during veno-arterial extracorporeal membrane oxygenation (VA-ECMO), but its clinical tradeoffs versus femoral return are uncertain. We reviewed observational studies comparing upper-body to femoral..

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Neuropsychological and structural brain abnormalities in adults with d-transposition of the great arteries: The Boston Circulatory Arrest Study

Abstract Introduction Neurocognitive impairments are frequent in congenital heart disease. The Boston Circulatory Arrest Study (BCAS) is a randomized trial comparing the developmental and neurological outcomes of newborns born with..

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Living-donor lung transplantation for patients on extracorporeal membrane oxygenation support: A case series

Abstract In Japan, the average waiting time for deceased-donor lung transplantation exceeds 900 days, and living-donor lung transplantation (LDLT) has been performed in a certain number of patients who are..

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Prolonged hypoxemia before tetralogy of Fallot surgery: Harmful or harmless?

Abstract Introduction Tetralogy of Fallot (TOF) is the most common cyanotic heart disease (CHD). The associated cardiac abnormalities disrupt oxygenation and depending on disease severity, infants with TOF syndrome are..

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Association between rewarming rate during cardiopulmonary bypass and postoperative delirium in patients receiving olanzapine after cardiac surgery: A retrospective cohort…

Abstract Background The relationship between rewarming rate during cardiopulmonary bypass (CPB) and postoperative delirium (POD) in cardiac surgery remains unclear. This retrospective study aimed to evaluate whether rapid rewarming is..

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Challenges in monitoring and titration of argatroban versus unfractionated heparin in extracorporeal membrane oxygenation

Abstract Objectives Anticoagulation during extracorporeal membrane oxygenation (ECMO) remains challenging. Direct thrombin inhibitors such as argatroban are increasingly proposed as alternatives to unfractionated heparin (UFH). We sought to characterize the..

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Acute rheumatic fever and rheumatic heart disease in Latin America: a contemporary review of epidemiology

Abstract Rheumatic heart disease (RHD) remains a significant public health challenge in Latin America, disproportionately affecting vulnerable populations despite global declines in disease prevalence and mortality. It is known that..

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Hemocompatible polymer coating for extracorporeal circulation circuit affects lactate levels during cardiopulmonary bypass surgery

Abstract Introduction Blood lactate level (LL) is a useful predictor of physiological issues during extracorporeal circulation (ECC) treatment. To determine variations in LL depending on the hemocompatible coatings used for..

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Vaso-active inotropic scores: Clinical value, pros and cons

Abstract OBJECTIVE Vasoactive-inotropic scores (VIS) are used as predictors of outcome in pediatric and adult patients with cardiogenic shock undergoing cardiac surgery. VIS is calculated by combining the doses of..

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Extracorporeal Carbon Dioxide Removal as a Multimodal Strategy for Severe Acute Respiratory Distress Syndrome: A Case Series

Abstract Severe acute respiratory distress syndrome (ARDS) is associated with substantial morbidity and mortality ranging from 37 to 44%. Although extracorporeal membrane oxygenation (ECMO) is often indicated in ARDS, it..

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International Variation in Cardiopulmonary Bypass-Associated Coagulation Management: A Cross-Sectional Survey

Abstract Background Considerable variability persists in coagulation management during cardiopulmonary bypass (CPB) supported cardiac surgery. This survey aimed to describe contemporary reported practices across international settings. Methods A cross-sectional, web-based..

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Universal modular strategy for constructing anticoagulant coatings on surfaces of medical devices

Abstract Thrombus on implants is dangerous, necessitating anticoagulant coatings for most of blood-contacting devices with various substances. So far, there is no universal strategy of the pertinent surface modification for..

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Extracorporeal membrane oxygenation liberation before heart transplantation in the modern allocation era: Predictors and one-year outcomes from the National OPTN/UNOS…

Abstract Background The clinical significance of ECMO liberation before heart transplantation remains poorly defined. Objectives To identify predictors of pre-transplant ECMO liberation and evaluate its association with 1-year post-transplant survival...

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Cardiovascular Involvement of Multisystem Inflammatory Syndrome in Children: A Multicentric Observational Study on Mid- and Long-term Follow-up with Cardiovascular Imaging

Abstract Background: Multisystem inflammatory syndrome in children (MIS-C) is a relatively rare complication of COVID-19, with frequent cardiovascular involvement, in terms of pericarditis, valvulitis, coronary aneurysms, and myocardial dysfunction/cardiogenic shock...

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Mechanical circulatory support strategy in post–myocardial infarction ventricular septal defect repair

Abstract Post–myocardial infarction (PMI) ventricular septal defect (VSD) repair is associated with high mortality., The pathophysiology varies based on the size of the infarction and the VSD, which results in..

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Perioperative hemostasis management in patients with von Willebrand disease undergoing cardiac surgery: A scoping review

Abstract First described in 1926 by Erik von Willebrand as hereditary pseudohemophilia, von Willebrand disease (vWD) is now recognized as the most common inherited bleeding disorder worldwide, with an estimated..

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Cerebral Arterial Gas Embolism in Cardiovascular and Aortic Procedures: A Narrative Review of the Mechanisms, Diagnosis, Management, and Prevention

Abstract Cerebral arterial gas embolism (CAGE) is an uncommon but potentially catastrophic complication of cardiothoracic surgery, extracorporeal circulation, mechanical circulatory support, and catheter-based cardiac interventions. During these procedures, gas may..

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Impact of Acute Kidney Injury on Hospitalization Outcomes in Patients with Chronic Kidney Disease Undergoing Cardiac Procedures with Cardiopulmonary Bypass…

Abstract Background Acute kidney injury (AKI) is a common complication after cardiac surgery and is associated with more infections, prolonged recovery, longer hospital stays, increased readmission rates, greater costs, and..

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ABO-incompatible pediatric lung transplant performed with immunoadsorption column system: A case report

Abstract An 11-month-old infant was admitted to the intensive care unit after cardiorespiratory arrest associated with the parainfluenza virus. Despite interventions, deterioration persisted. Echocardiography revealed severe pulmonary hypertension, tricuspid gradient..

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Population pharmacokinetics of methylprednisolone in neonates and paediatric patients undergoing cardiac surgery with cardiopulmonary bypass

Abstract Purpose Methylprednisolone is used during paediatric cardiac surgery with cardiopulmonary bypass to attenuate the systemic inflammatory response. However, developmental differences in drug disposition and cardiopulmonary bypass–related factors contribute to..

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Factors contributing to thrombocytopenia after cardiac surgery; towards defining coagulation-friendly cardiac surgery

Abstract Introduction The anticoagulation strategy and the cardiopulmonary bypass management represent two core elements of the intraoperative care of the cardiac surgery patient. The ideal approach remains an issue of..

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Cardiopulmonary Bypass Priming Practices and Blood Product Availability in Neonatal Cardiac Surgery: A European Survey

Abstract Neonatal cardiac surgery requires cardiopulmonary bypass (CPB) strategies that minimize hemodilution while maintaining adequate oxygen delivery and hemostatic balance. Despite increasing emphasis on patient blood management (PBM), contemporary CPB..

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Physiological anticoagulant deficiencies: pathogenesis, diagnosis, and clinical implications

Abstract Physiological anticoagulants are essential regulators of coagulation, and their deficiency shifts hemostasis toward a prothrombotic state, increasing the risk of venous thromboembolism. The main physiological anticoagulants, antithrombin (AT), protein..

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Thromboelastography Parameters Thresholds for Optimal Prediction of Major Bleeding after On-Pump Cardiac Surgery

Abstract As cardiac surgery volumes increase worldwide, major bleeding remains a significant complication following cardiopulmonary bypass (CPB) surgery. Accurate prediction of postoperative hemorrhage risk is crucial. This study aimed to..

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Time to Pediatric Extracorporeal Membrane Oxygenation Circuit Failure: An Extracorporeal Life Support Organization Registry-Based Study

Abstract Circuit thrombosis and mechanical failure are important complications during extracorporeal membrane oxygenation (ECMO), but expected circuit duration and predictors of circuit failure remain poorly defined. We performed a retrospective..

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Systematic review and network meta-analysis of non-pharmacological interventions for inadequate perfusion in hypothermic circulatory arrest

Abstract This network meta-analysis aimed to compare different non-pharmacological interventions for insufficient perfusion after hypothermic circulatory arrest, a key technique in aortic arch surgery. The authors retrieved and analyzed 60..

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Standardized femoral artery cannulation and ischemia-prevention protocol for minimally invasive cardiac surgery

Abstract Objectives In minimally invasive cardiac surgery, femoral artery cannulation is widely used; however, it may cause lower-limb ischemia. We developed a standardized patient-selection strategy, a femoral artery–cannulation technique, and..

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Extracorporeal Membrane Oxygenation Combined With Embolectomy May Yield Better Outcomes Than Extracorporeal Membrane Oxygenation Alone or With Thrombolysis for Acute…

Abstract Veno-arterial extracorporeal membrane oxygenation (ECMO) is used to support patients with high-risk pulmonary embolism (HR-PE) with cardiogenic shock, but data on mid- and long-term outcomes after reperfusion remain limited...

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The immunomodulatory effect of continuous ultrafiltration during pediatric cardiac surgery

Abstract Background Cardiopulmonary bypass is associated with systemic inflammation during pediatric cardiac surgery and features elevated systemic concentrations of complement, cytokines and chemokines. The objective of this study is to..

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Pediatric Respiratory Failure and Support With Prolonged Extracorporeal Membrane Oxygenation: Multicenter Cohort Using the Extracorporeal Life Support Organization Registry, 1989–2021

Abstract Objectives: To characterize outcomes in children supported with 14 days or more of extracorporeal membrane oxygenation (ECMO) for respiratory indications. Design: Retrospective analysis of the Extracorporeal Life Support Organization..

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