Yearly Archives: 2025

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Less Is More for Bleeding Management Algorithms in Cardiac Surgery: A Network Meta-Analysis and Meta-Regression of Randomized Studies

Abstract BACKGROUND:  Major bleeding after cardiac surgery is still a relatively common complication, requiring red blood cell (RBC) transfusions and use of procoagulants. The existing guidelines recommend a bleeding management..

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Restrictive versus liberal oxygenation in patients undergoing cardiopulmonary bypass-assisted heart surgery: a randomised controlled trial

Abstract Background Maintaining adequate oxygen delivery during cardiopulmonary bypass (CPB)-assisted cardiac surgery is crucial, but hyperoxia has been suggested to cause organ injury. We compared the effects of restrictive vs liberal oxygenation..

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Radiomics-enhanced modelling approach for predicting the need for ECMO in ARDS patients: a retrospective cohort study

Abstract Decisions regarding veno-venous extracorporeal membrane oxygenation (vv-ECMO) in patients with acute respiratory distress syndrome (ARDS) are often based solely on clinical and physiological parameters, which may insufficiently reflect severity..

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The evolution of artificial red blood cells and recent advances in state-of-the-art oxygen carrier technologies: a narrative review

Abstract The demand for homologous blood transfusions has reached an unprecedented level, driven by a declining donor population and the ever-increasing need for blood products. While significant advancements have been..

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Prolonged Mechanical Ventilation Before Venovenous Extracorporeal Membrane Oxygenation and In-Hospital Mortality in Patients With Acute Respiratory Distress Syndrome

Abstract Objectives:  To evaluate the relationship between the duration of pre-extracorporeal membrane oxygenation (ECMO) mechanical ventilation and mortality in acute respiratory distress syndrome (ARDS) patients undergoing venovenous ECMO. Design:  Retrospective..

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Delivery of oxygen during cardiopulmonary bypass and associated clinical outcomes among adult cardiac surgery patients: A systematic review

Abstract Purpose Oxygen delivery (DO2) during cardiopulmonary bypass (CPB) is critical in preventing postoperative complications in adult cardiac surgery. This systematic review aimed to assess the relationship between intraoperative DO2 during..

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Gut Microbiota, Microbial Metabolites, and Inflammation in Cardiac Surgery: Implications for Clinical Outcomes—A Narrative Review

Abstract Cardiac surgery, particularly procedures involving cardiopulmonary bypass (CPB), is associated with a high risk of postoperative complications, including systemic inflammatory response syndrome (SIRS), postoperative atrial fibrillation (POAF), and infection...

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European Resuscitation Council Guidelines 2025

Abstract The 2025 European Resuscitation Council (ERC) Guidelines present the most up-to-date evidence-based guidelines for the practice of resuscitation across Europe. The ERC Guidelines 2025 are based on evidence produced..

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Robustness of Randomized Controlled Trials Evaluating Acute Normovolemic Hemodilution as a Blood Conservation Strategy in Cardiac Surgery

Abstract Objective To evaluate the robustness of randomized controlled trials (RCTs) investigating acute normovolemic hemodilution (ANH), a blood conservation strategy designed to reduce transfusion requirements, in cardiac surgery using the..

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Controlling intraoperative hyperglycemia in the cardiac surgical patient using the computerized electronic insulin dose calculator

Abstract Perioperative hyperglycemia is associated with increased morbidity and mortality. We report the findings of our quality improvement project on the use of an electronic insulin dosing calculator (EIC) to..

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Residual blood management after ECMO weaning: Reinfuse, salvage, or discard?

Abstract Extracorporeal membrane oxygenation (ECMO) supports patients with severe refractory cardiac or respiratory failure but managing residual circuit blood after weaning lacks consensus. After decannulation, the oxygenator and circuit retain..

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Towards Portable Leg Perfusion: Initial Prototype Testing of a Selective Leg Perfusion System

Abstract Introduction Limb loss after combat injury is a major factor for morbidity in combat casualties. Although tourniquets clearly save lives, they can result in prolonged ischemia in large scale..

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A Fick tool: connecting Fick’s law and principle in teaching pulmonary gas exchange

Abstract In humans, the transfer of respiratory gases between the atmosphere and living cells depends on their diffusion between lungs, blood, and cells, as well as their advective transport by..

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Cerebral oximetry in antegrade versus retrograde cerebral perfusion in aortic surgery

Abstract Background The optimal cerebral protection strategy during complex aortic surgery remains controversial, and various brain monitoring modalities are used to provide different information to improve cerebral protection. This study..

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Organ Donation after Extracorporeal Cardiopulmonary Resuscitation: Clinical and Ethical Perspectives

Abstract Extracorporeal cardiopulmonary resuscitation (ECPR) has evolved into a life-saving therapy for select cardiac arrest patients, yet a growing body of evidence suggests it also holds promise as a bridge..

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Infection risks in patients treated by continuous renal replacement therapy and extracorporeal membrane oxygenation

Abstract Purpose of review  This review addresses the growing concern over nosocomial infections in patients undergoing extracorporeal membrane oxygenation (ECMO) and/or continuous renal replacement therapy (CRRT). As the use of..

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Delirium after coronary artery bypass grafting with cardiopulmonary bypass surgery: The value of cerebral autoregulation

Abstract Introduction Postoperative delirium affects up to 60% of cardiac surgical patients. No reliable gold standard method exists for preventing delirium after cardiac surgery. An example of patient-personal monitoring is..

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Covalent Organic Framework-Based Porous Anticoagulant Materials for Extracorporeal Blood Circulation

Abstract Preventing coagulation during extracorporeal blood circulation is critical for clinical treatments. Developing anticoagulant materials for key components can reduce reliance on systemic anticoagulants and improve safety. However, such materials..

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Resection of Juvenile Nasopharyngeal Angiofibroma Using Le Fort I Approach and Deep Hypothermic Circulatory Arrest

Abstract Juvenile nasopharyngeal angiofibroma (JNA) is a rare, highly vascular benign tumor that predominantly affects adolescent males. Despite its benign histology, JNA may exhibit aggressive behavior, often invading adjacent anatomic..

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The Association of Physical Therapy Timing and Frequency With Functional Outcomes in Patients Supported With Extracorporeal Membrane Oxygenation: A Single-Center…

Abstract IMPORTANCE:  Physical therapy (PT) interventions for patients supported with extracorporeal membrane oxygenation (ECMO) is thought to help preserve independence, but the impact of PT frequency on ECMO recovery is..

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Outcomes of Palliative Care in Extracorporeal Life Support: A Systematic Review

Abstract Context Use of palliative care in extracorporeal life support (ECLS) has increased, but its impact on patient- and family-centered outcomes remains unclear. Objective To examine the relationship between specialty..

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Calculation of blood loss in cardiac surgery: How should we monitor?

Abstract Background The bleeding in cardiac surgery remains a significant clinical problem. There is no “gold standard” method to quantify blood loss. Traditional measurement of drainage volume often underestimates or..

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Variation in Techniques of Selective Antegrade Cerebral Perfusion in Neonates Undergoing Aortic Arch Reconstruction: A Comprehensive Review

Abstract Background Despite the widespread adoption of selective antegrade cerebral perfusion (SACP) for neonatal aortic arch reconstruction, significant variability in techniques persists across institutions, thus reflecting limited supporting data and..

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The Effect of Autologous Blood Transfusion in Open Heart Procedures on the Requirement of Allogeneic Blood Products

Abstract Objectives The aim of the study was to evaluate the effect of autologous blood transfusion on the requirement of allogeneic blood products and the change in hemoglobin levels in..

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Developing a Protocol for Therapeutic Plasma Exchange in Tandem With Continuous Renal Replacement Therapy (CRRT) and ExtraCorporeal Membrane Oxygenation (ECMO)…

Abstract Therapeutic plasma exchange (TPE) in pediatric patients presents many challenges, including management of a large extracorporeal volume (ECV) and calcium replacement for patients who may not be able to..

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Rapid Cycle Deliberate Practice Extracorporeal Membrane Oxygenation Simulation in the Cardiac Catheterization Laboratory

Abstract Delays in mechanical circulatory support initiation, in particular extracorporeal membrane oxygenation (ECMO), can exceed an hour while awaiting a specialized shock team. Delays can negatively impact patient outcomes. To address..

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A Canadian Experience With a Percutaneous Microaxial Ventricular Assist Device in Children With Cardiogenic Shock

Abstract Background The experience of a percutaneous microaxial (Impella)  in children with  is limited. The primary objective of this study was to review our institutional clinical outcomes of Impella use in children..

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Management of Emergency Cardiopulmonary Bypass Failure During Robot-Assisted Mitral Valve Repair: Successful Recovery With Hypothermia and Centrifugal Pump Exchange

Abstract CARDIOPULMONARY BYPASS (CPB) is an essential component of cardiac surgery, and its unexpected failure during surgery can compromise circulatory and respiratory management, potentially endangering the patient's life. In the..

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Pulmonary protective and antiinflammatory effects of dexmedetomidine in cardiac surgery with cardiopulmonary bypass: a systematic review and metaanalysis

Abstract Objective This study aims to investigate pulmonary protective and antiinflammatory effects of dexmedetomidine (DEX) in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) by meta-analysis. Methods Six databases were..

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Extracorporeal Membrane Oxygenation Cannulation by Intensivists: A Systematic Review and Meta-Analysis

Abstract Purpose To summarize the currently available evidence regarding the effectiveness and safety of extracorporeal membrane oxygenation (ECMO) cannulation performed by intensivists. Methods We conducted a systematic search of MEDLINE,..

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