Yearly Archives: 2025

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Thrombocytopenia During Venovenous Extracorporeal Membrane Oxygenation in Adult Patients With Bacterial, Viral, and COVID-19 Pneumonia

Abstract Contact of blood with artificial surfaces triggers platelet activation. The aim was to compare platelet kinetics after venovenous extracorporeal membrane oxygenation (V-V ECMO) start and after system exchange in..

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Real-time prediction of heparin concentration in blood extracorporeal circulation by relaxation time distribution (RTD)

Abstract In blood extracorporeal circulations such as hemodialysis (HD) and extracorporeal membrane artificial lung (ECMO) during the surgical operation, the real-time and noninvasive prediction of heparin concentration c is necessary over the..

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Use of Intraoperative Hemostatic Checklists for Blood Management in Patients Undergoing Cardiac Surgery: A Scoping Review

Abstract Background Using intraoperative hemostatic checklists may improve rates of surgical re-exploration and utilization of allogenic blood products in patients undergoing cardiac surgery. In this review, the authors explore the..

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Platelet proteomics: Clinical implications – Decoding the black box!

Abstract Platelets are anucleate blood cells traditionally associated with hemostasis but now increasingly recognized for their multifaceted roles in immunity, inflammation, and tissue repair. Advances in platelet proteomics, employing high-throughput..

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The Potential Role of Albumin in Reducing Cardiac Surgery–Associated Acute Kidney Injury: A Randomized Controlled Trial

Abstract Objectives Cardiac surgery–associated acute kidney injury (CSA-AKI) is a common complication with high morbidity and mortality. This study was designed to determine whether adding human albumin to the cardiopulmonary..

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Prebypass Critical Closing Pressure Predicts Acute Kidney Injury After Cardiopulmonary Bypass

Abstract Objectives Optimal blood pressure goals during cardiopulmonary bypass (CPB) remain uncertain and new metrics to individualize perfusion targets are needed. Critical closing pressure (Pcrit) is a fundamental property of..

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Development of and recovery from acute kidney injury after cardiac surgery: Randomized phase 2 trial of the hepatocyte growth factor…

Abstract Objectives To investigate the safety and efficacy of ANG-3777, a hepatocyte growth factor mimetic, in mitigating the risk of acute kidney injury (AKI) in patients undergoing cardiac surgery with..

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Antithrombotic and Antimicrobial Potential of S-Nitroso-1-Adamantanethiol–Impregnated Extracorporeal Circuit

Abstract This study presents the utilization of a novel, highly lipophilic nitric oxide (NO) donor molecule, S-nitroso-1-adamantanethiol (SNAT), for developing an NO-emitting polymer surface aimed at preventing thrombus formation and bacterial..

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Strategies for adapting under pressure: an interview study in intensive care units

Abstract Background Healthcare systems are operating under substantial pressures. Clinicians and managers are constantly having to make adaptations, which are typically improvised, highly variable and not coordinated across teams. This study..

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Fibrinolytic activity in infants undergoing cardiac surgery on cardiopulmonary bypass with routine tranexamic acid

Abstract BACKGROUND  Fibrinolytic activity contributes to bleeding after cardiopulmonary bypass (CPB). OBJECTIVE  Our objectives were, in a group of infants undergoing cardiac surgery with CPB: to document the extent of..

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Innovative balloon-inflatable venous cannula for enhanced cardiopulmonary bypass in minimally invasive cardiac surgery

Abstract OBJECTIVES Minimally invasive cardiac surgery (MICS) struggles with effective caval isolation and cannulation for cardiopulmonary bypass (CPB). We aimed to develop a novel MICS venous cannula, eliminating external manipulations...

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Low-Range Heparin and Protamine Detection: A Single-Center Prospective Diagnostic Study

Abstract Objectives The detection of low-range heparin activity is important to correctly assess heparin reversal and rebound, especially after cardiopulmonary bypass. Current parameters are either not available at point-of-care (anti-Xa..

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Development and validation of a nomogram for predicting perioperative transfusion in children undergoing cardiac surgery with CPB

Abstract Background Timely recognition of perioperative red blood cell transfusion (PRT) risk is crucial for developing personalized blood management strategies in pediatric patients. In this study, we sought to construct..

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Immediate Clinical Complications Occurring During Membrane Change in Patients on Veno-Venous Extracorporeal Membrane Oxygenation

Abstract The clinical tolerance of extracorporeal membrane oxygenation (ECMO) membrane changes in acute respiratory distress syndrome (ARDS) patients under veno-venous ECMO (VV-ECMO) has not been reported. The aim of this..

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The circulatory arrest recovery ammonia problem (CARAP) hypothesis: A proton magnetic resonance spectroscopy (1H-MRS) study of brain metabolism during neonatal…

Abstract Objective Congenital heart disease affects 1% of US births, with many babies requiring major cardiothoracic surgery under cardiopulmonary bypass (CPB), exposing the more critical patients to neurodevelopmental impairment. Optimal..

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Performance of Hemochron ACT-LR and ACT+ Test Cuvettes in Monitoring Low to Moderate Heparin Concentrations: An In Vitro Study

Abstract Objectives According to the manufacturer, the Hemochron ACT-LR cuvette is designated for heparin concentrations of 0 to 2.5 IU/mL, while the optimal concentration range for the ACT+ cartridge is..

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Reliability of Tracheal Temperature as a Measurement of Core Body Temperature During Cardiac Surgery Using Cardiopulmonary Bypass

Abstract Background: To compare tracheal temperature (TET) with nasopharyngeal temperature (TNP) in patients undergoing cardiac surgery using cardiopulmonary bypass (CPB).    Methods: TET was measured using a thermistor in the cuff..

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Effects of pulsatile flow on postoperative recovery in adult cardiac surgery with cardiopulmonary bypass: A systematic review and meta-analysis of…

Abstract Background The role of pulsatile versus non-pulsatile flow during cardiopulmonary bypass (CPB) is still in debate. This systematic review aimed to comprehensively assess the impact of pulsatile versus non-pulsatile..

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Mechanical circulatory support: when, how, and for whom

Abstract Cardiogenic shock represents a critical condition in which the heart is unable to maintain adequate circulation leading to insufficient tissue perfusion and end-organ failure. Temporary mechanical circulatory support offers..

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Extracorporeal Membranous Oxygenation Associated With Tracheal Procedures: An Extracorporeal Life Support Organization (ELSO) Registry Analysis

Abstract Extracorporeal membrane oxygenation (ECMO) has been primarily used for respiratory and circulatory failure, but its airway-related use has not been investigated well. Tracheal procedures are a situation when ECMO..

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International Graduate Assistant Position in Perfusion

Program Description: The SUNY Upstate Medical University is seeking applicants to fill a paid educational assistantship in the Department of Cardiovascular Perfusion. One international candidate per year will be selected..

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2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery

Preamble Clinical practice guidelines consolidate and evaluate all pertinent evidence on a specific topic available at the time of their formulation. The goal is to assist physicians in determining the..

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EQUILÍBRIO ACIDO BASE - Aula 80

Prof. Elio Carvalho é Biomédico, Microbiologista e Perfusionista pela Unicamp, CLAP e SBCEC. É perfusionista do Hospital de Clínicas da Unicamp e Coordenador do Curso da Unicamp de Perfusionistas. É..

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Population pharmacokinetic model of tranexamic acid in patients who undergo cardiac surgery with cardiopulmonary bypass

Abstract Purpose Tranexamic acid (TXA) is widely used as an antifibrinolytic drug. However, studies to determine the optimal blood concentration of TXA have produced inconsistent results. During cardiac surgery, cardiopulmonary..

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Long-term outcomes of patients who received extracorporeal cardiopulmonary resuscitation (ECPR) following in-hospital cardiac arrest: Analysis of EXCEL registry data

Abstract Objective To describe the six-month functional outcomes of patients who received extracorporeal cardiopulmonary resuscitation (ECPR) following in-hospital cardiac arrest (IHCA) in Australia. Design Secondary analysis of EXCEL registry data...

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Interhospital variability in 180-day infections following cardiac surgery

Abstract Objective To evaluate hospital-level variation in infections following cardiac surgery and develop and evaluate a 180-day infection quality metric. Methods This study evaluated Medicare claims that were merged with..

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Evaluation of the Feasibility of Transfusing Leukocyte Depletion Filter–Processed Intraoperative Cell Salvage Blood in Metastatic Spine Tumor Surgery: Protocol for…

Abstract Background: Metastatic spine tumor surgery (MSTS) is often complex and extensive leading to significant blood loss. Allogeneic blood transfusion (ABT) is the mainstay of blood replenishment but with immune-mediated..

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Implementation of a Checklist Tool to Improve Understanding of Rapid Response Team Protocols

Abstract Background and Objectives: Rapid response teams (RRT) are multidisciplinary teams activated to assess patients outside of the Intensive Care Unit (ICU) and require a shared framework for approaching a deteriorating..

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Extracorporeal membrane oxygenation for Chinese neonates with severe respiratory and cardiac failure

Abstract Objective We aimed to outline the experience with extracorporeal membrane oxygenation (ECMO) for respiratory and cardiac failure in neonates in our institution and compare our results with those from..

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