Yearly Archives: 2025

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Pharmacokinetics and Pharmacodynamics of Analgesic and Anesthetic Drugs in Patients During Cardiac Surgery With Cardiopulmonary Bypass: A Narrative Review

Abstract Cardiopulmonary bypass (CPB) impacts pharmacokinetics and -dynamics of drugs used during cardiac surgery. These alterations can lead to changes in drug efficacy resulting in under- or overdosing. This review..

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The value of cerebral and somatic near-infrared spectroscopy within an integrated tissue perfusion monitoring strategy in cardiac surgery: A prospective…

Abstract Introduction We sought to evaluate cerebral and somatic oximetry in an integrated tissue perfusion monitoring strategy. Method Thirty adult patients undergoing full-spectrum cardiac surgery with Minimal Invasive Extracorporeal Circulation..

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Risk Factors and Predictive Model for Stress Hyperglycemia After Cardiac Surgery in Non-Diabetic Patients

Abstract Objective: To create and verify a model that predicts the risk of stress hyperglycemia (SHG) in patients without diabetes after cardiac surgery. Design: Retrospective analysis. Methods: This retrospective analysis analyzed patients without..

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Active Chest Tube Clearance Added to an Enhanced Recovery After Cardiac Surgery (ERAS) Program Improves Outcomes and Reduces Resource Utilization

Abstract Objective: We initiated a cardiac enhanced recovery after cardiac surgery (ERAS) program in early 2019, protocolized it and applied it to all patients in 2020, and added the use..

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Combining procalcitonin, c-reactive protein, and white blood cell count in predicting infections in pediatric open cardiac surgery with cardiopulmonary bypass

Abstract Objective This study aimed to evaluate the validity of models using Procalcitonin (PCT) alone and PCT combined with other biomarkers to predict early infection after pediatric open-heart surgery with..

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Prevention and Management of Spinal Cord Ischemia After Aortic Surgery: An Umbrella Review

Abstract Background/Objectives: Spinal cord injury is a devastating complication of aortic surgery, with significant morbidity and mortality. This review aimed to summarize the current literature on preventing and managing spinal cord..

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Normothermic Circulatory Arrest with Antegrade Cerebral Perfusion for Type A Aortic Dissection

Abstract Background Deep hypothermic circulatory arrest is the standard approach for the surgical repair of acute type A aortic dissection. This study aimed to evaluate the feasibility and outcomes of..

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Enhanced recovery in cardiac surgery patients with frailty through comprehensive perioperative nursing interventions: A randomized controlled trial

Abstract Objective To evaluate the effects of comprehensive perioperative nursing interventions on postoperative recovery in cardiac surgery patients with frailty, with a focus on physical activity, nutritional status, and cognitive..

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A prospective non-inferiority trial of pathogen reduced platelets compared to non-pathogen reduced platelets for correction of viscoelastic platelet function testing…

Abstract Background Cardiac surgery on cardiopulmonary bypass (CPB) may alter platelet (PLT) function causing bleeding. The goal of this study is to evaluate the hemostatic effect of PRT-PLTs compared to..

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Nociceptive and non-nociceptive pain in critical care patients after cardiac surgery

Abstract Aim: To assess pain intensity during nociceptive (endotracheal suctioning) and non-nociceptive (body temperature measurement) procedures in critically ill patients after cardiac surgery. Methods: A descriptive and cross-sectional design was..

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Achieving Neuroprotection in the Setting of Early Extubation During Infant Cardiac Surgery: A Prospective, Randomized, and Blinded Study

Abstract Background: This study aimed to investigate the impact of early extubation on stress response and neurodevelopmental outcomes after pediatric cardiac surgery utilizing cardiopulmonary bypass (CPB). Methods: In this single-center prospective pilot..

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High Flow, High-Pressure Retrograde Cerebral Perfusion at 28°C is Safe and Effective for Hemiarch Replacement of the Ascending Aorta

Abstract Background/Objective Traditional retrograde cerebral perfusion (RCP) parameters may be suboptimal for washout of debris during hemiarch replacement of the ascending aorta, so we have designed a protocol of increased..

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Safety and limitations of line pressure-targeted cerebral perfusion strategy in aortic arch surgery

Abstract OBJECTIVES The optimal flow rate for selective antegrade cerebral perfusion during aortic arch surgery is unknown. While 10–15 ml/kg/min is generally recommended, our centre has adopted a line pressure-targeted, relatively..

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Outcomes of a Standardized Protocol on the Management of Acute Type A Aortic Dissection: A Retrospective Cohort Study

Abstract Background Acute Type A aortic dissection (AAAD) is a life-threatening condition, with surgery being the recommended treatment. However, there is ongoing debate regarding the optimal surgical procedure. This study..

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Managing Coagulation Using the Sonoclot Analyzer in Patients With Disseminated Intravascular Coagulation

Abstract Background Evidence for the effectiveness of the Sonoclot analyzer in improving clinical outcomes in disseminated intravascular coagulation (DIC) is lacking. Objective To evaluate the effectiveness of an algorithm based..

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Intraoperative blood recovery in cancer surgery: A pilot study evaluating local feasibility

Abstract Background Cancer surgery patients are among those most at high risk of perioperative anemia. Allogeneic transfusions are linked to adverse effects, including increased cancer recurrence and mortality. Intraoperative cell..

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Effects of inhaled anaesthetic agents on the oxygen dissociation curve: An updated discussion

Abstract The oxygen dissociation curve is a critical concept in understanding how oxygen is transported in the blood and delivered to tissues. In anaesthesia, inhaled anaesthetic agents are the fundamental..

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Prevalence and impact of ECMO cannula colonization: a single center study

Abstract During ECMO therapy, infections are common and have substantial impact on treatment outcomes. However, data on the prevalence and clinical impact of microbial ECMO cannula colonization are scarce. Between..

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Electroencephalogram monitoring during anesthesia and critical care: a guide for the clinician

Abstract Perioperative anesthetic, surgical and critical careinterventions can affect brain physiology and overall brain health. The clinical utility of electroencephalogram (EEG) monitoring in anesthesia and intensive care settings is multifaceted,..

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Bleeding Definitions in Pediatric Extracorporeal Membrane Oxygenation (ECMO) Studies: A Systematic Review and Meta-Analysis

Abstract Extracorporeal membrane oxygenation (ECMO) supports severe cardiorespiratory failure but carries a significant bleeding risk. This systematic review aims to report bleeding definitions in studies involving neonates and children treated..

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Impact of a Generated Magnetic Field at the Schumann Resonance Frequency on Skin Blood Perfusion and Peripheral Pulse Amplitudes

Abstract A pilot study was conducted in six young adult male volunteers (25.8±1.3 years) to determine if there was evidence of an effect of a locally applied magnetic field at..

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Venoarterial Extracorporeal Membrane Oxygenation: A Better Pressor

Abstract PROFOUND HYPOTENSION AND end-organ hypoperfusion are most often the consequence of inadequate systemic blood flow from primary cardiac failure (cardiogenic shock) or hemorrhage (hemorrhagic shock). However, profound hypotension may..

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Clinical assessment of cannula performance during adult minimally invasive valve surgery using predictive mathematical models

Abstract OBJECTIVES Peripheral cannula selection in minimally invasive cardiac surgery (MICS) is crucial, as venous drainage limitations during cardiopulmonary bypass (CPB can impair end-organ perfusion and overall outcomes. This study..

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Extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest

Abstract When conventional cardiopulmonary resuscitation (CCPR) cannot restore spontaneous circulation, the initiation of venoarterial extracorporeal membrane oxygenation during refractory cardiac arrest—known as extracorporeal CPR (ECPR)—might restore circulation and adequate tissue..

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Extracorporeal membrane oxygenation for systemic lupus erythematosus: An ELSO registry analysis

Abstract The success of extracorporeal membrane oxygenation (ECMO) in treating Systemic Lupus Erythematosus (SLE) and the risk factors associated with mortality remain uncertain.   Methods: We describe the survival outcomes at..

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Extracorporeal Membrane Oxygenation Cannulation Site Affects Coronary and Cerebral Perfusion When Combined With Intra-Aortic Balloon Pump

Abstract The use of intra-aortic balloon pump (IABP) alongside venoarterial extracorporeal membrane oxygenation (VA-ECMO) in critically ill patients presenting refractory cardiogenic shock raises questions regarding its impact on organs perfusion...

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A Comprehensive Review of Left Atrial Venoarterial Extracorporeal Membrane Oxygenation

Abstract Cardiogenic shock (CS) in patients with structural heart disease (SHD) and severe valvular abnormalities poses unique challenges to traditional mechanical circulatory support (MCS) strategies, such as intra-aortic balloon pumps..

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Bullying, Harassment, and Undermining Behavior in Cardiothoracic Surgery in the United Kingdom and Ireland

Abstract Background Bullying, harassment, and undermining behavior has a profound detrimental effect on the multiprofessional team, patient safety, and clinical outcomes. Bullying creates a poor working and training environment, increasing..

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