Yearly Archives: 2025

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Delayed neurological recovery in patients after extracorporeal resuscitation compared to conventional resuscitation. Implications for outcome assessment after cardiac arrest

Abstract Introduction Extracorporeal cardiopulmonary resuscitation (eCPR) is a rescue therapy for refractory cardiac arrest, with evidence suggesting improved outcomes when performed at experienced centres. Unlike conventional CPR (cCPR), eCPR patients..

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Re-evaluating the impact of mechanical ventilation strategies during cardiac surgery with cardiopulmonary bypass: work in progress

Abstract Cardiac surgery is a commonly performed procedure worldwide, with an estimated 1–1.5 million cases per year and figures destined to increase in the next few years []. A significant..

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Blood perfusion through ventricular assist devices induces erythrocytes to interact with leukocytes

Abstract Implantations of  (VADs) have significantly improved  and life expectancy of end-stage heart failure patients. However, despite the advancements in the VAD designs and patient management protocols, the VAD recipients remain at..

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Do Sex Differences Matter in Cardiac Surgery-Associated Acute Kidney Injury? – A Narrative Review

Abstract Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common complication following cardiac surgery. Despite growing awareness of sexual dimorphism in cardiovascular and chronic kidney disease, little is known about..

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Impact of Venoarterial Extracorporeal Membrane Oxygenation on Hemodynamics and Cardiac Mechanics: Insights From Pressure-Volume Loop Analysis

Abstract Venoarterial extracorporeal membrane oxygenation (VA-ECMO) serves as a critical mechanical circulatory support modality, sustaining systemic circulation in cases of severe cardiac failure or cardiac arrest. While VA-ECMO improves hemodynamics,..

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Knowledge domains and hotspots in corticosteroid use for cardiac surgery: a 23-Year bibliometric and visualized analysis

Abstract Background The safety and efficacy of prophylactic corticosteroid administration during the perioperative period of cardiac surgery have undergone extensive and comprehensive examination. In this study, we conducted a bibliometric..

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The intra-aortic balloon pump: a modern practical perspective

Abstract Purpose of review  After more than 50 years from its invention, the intra-aortic balloon pump (IABP) is still one of the most widely used mechanical circulatory support devices to..

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Everolimus and Low-Dose Tacrolimus After Heart Transplant in Children

Abstract Importance  Studies suggest that everolimus may reduce the risk of rejection, cardiac allograft vasculopathy (CAV), chronic kidney disease (CKD), and cytomegalovirus (CMV) after heart transplant. Everolimus use is controversial because..

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Nutritional support in pediatric patients with extracorporeal membrane oxygenation: new insights

Abstract Nutritional support in pediatric patients receiving extracorporeal membrane oxygenation (ECMO) therapy is controversial. Although ECMO is increasingly used in pediatric intensive care units, there is no consensus on the..

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Intraoperative hypotension prediction in cardiac and noncardiac procedures: is HPI truly worthwhile? A systematic review and meta-analysis

Abstract Background Intraoperative hypotension (IOH), defined as a mean arterial pressure (MAP) below 65 mmHg, is a common complication during surgery and is associated with significant postoperative morbidity, including acute..

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Is it Time to Upgrade Neuromonitoring in ECPR Recipients to Evaluate Cerebral Perfusion Imbalances Adequately?

Abstract Veno-arterial extracorporeal membrane oxygenation (ECMO) brings many monitoring pitfalls due to the countercurrent blood flow, which may create left ventricular overload and perfusion imbalances between the two cerebral hemispheres...

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Exploring the Association Between Early PaCO2 Correction Speed and Cerebrovascular Autoregulation in a Porcine Model of Extracorporeal Resuscitation

Abstract Background Prior clinical research demonstrated that rapid reduction in arterial carbon dioxide (PaCO2) levels during extracorporeal membrane oxygenation (ECMO) is associated with acute brain injury (ABI), which may be..

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Relationship between intraoperative blood pressure variability and postoperative acute kidney injury in pediatric cardiac surgery

Abstract Background Cardiac surgery-associated acute kidney injury (CSA-AKI) is a notably common complication in pediatrics, with an incidence rate ranging from 15 to 64%. This rate is significantly higher than..

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Immediate post-ECPR management strategies in the prehospital and critical care transport medicine environments

Abstract Despite advancements in care, out-of-hospital cardiac arrest has a low survival rate. Extracorporeal cardiopulmonary resuscitation (ECPR) has shown improved outcomes in select cases, notably in the ARREST trial. However,..

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High-fidelity extracorporeal membrane oxygenation simulation in medical training: A review and opportunities for the future

Abstract Background: The growing popularity of extracorporeal membrane oxygenation (ECMO) necessitates adequate education and training of the multidisciplinary teams caring for these medically complex patients. Simulation-based education (SBE) has been used..

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Implantation of integrated magnetically levitated biventricular assist devices (DuoCor) – a single center clinical experience

Abstract Background:  End-stage heart failure remains a major global health challenge with high mortality. While heart transplantation is the gold-standard treatment, the scarcity of donor hearts necessitates alternative therapies. Left..

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Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia

Abstract Background Heparin-induced thrombocytopenia (HIT) is an immune-mediated platelet disorder caused by antibodies that target complexes of platelet factor 4 (PF4) and heparin. HIT has been characterized as a polyclonal..

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Comparison of Endoaortic Balloon Occlusion and Transthoracic Aortic Clamp for Minimally Invasive Cardiac Surgery: Systematic Review and Meta-analysis

Abstract This meta-analysis aimed to compare short-term outcomes in patients undergoing minimally invasive cardiac surgery (MICS) using endoaortic balloon (EAB) and transthoracic aortic clamp (TAC) techniques. A comprehensive search of..

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The Evolving Role of Extracorporeal In Situ Perfusion Technology in Organ Donor Recovery with Donation After Circulatory Determination of Death…

Abstract The need for organs suitable for transplantation has continued to rise as need outweighs availability. Increased demand has driven innovation in the field. Over the past ten years, donation..

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Comparative analysis of large language models and clinician responses in patient blood management knowledge

Abstract BACKGROUND: Large language models (LLMs) are increasingly used in the medical field and have the potential to reduce workload and improve treatment procedures in clinical practice. This study evaluates..

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Physiological and clinical effects of two ultraprotective ventilation strategies in patients with veno-venous extracorporeal membrane oxygenation: the ECMOVENT study

Abstract Purpose The optimal ventilation strategy in acute respiratory distress syndrome (ARDS) patients with veno-venous extracorporeal membrane oxygenation (VV-ECMO) remains unknown. We aimed to compare the effects of two ultra-protective..

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Norepinephrine pharmacolexicology: a chronological review of dose reporting and the implications of salt formulations

Abstract Uncertainties in norepinephrine dose reporting due to variable labeling practices secondary to salt formulation considerations have resulted in significant clinical and research challenges, potentially leading to impaired comparability across..

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Temporal trends and risk factors for bleeding and thrombosis in pediatric ECMO: A multicenter cohort study

Abstract Introduction Bleeding and thrombosis are major causes of morbidity and mortality in pediatric extracorporeal membrane oxygenation (ECMO), yet their evolving, time-dependent risks remain poorly defined. This study evaluated clinical..

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Optimal 6-hour window for salvaged mediastinal blood retransfusion after cardiovascular surgery: an in vitro quality and safety analysis

Abstract Background - Postoperative hemorrhage is a significant complication of cardiovascular surgery. Although autologous cell salvage is safe and effective for preserving patients' blood, its use in the postoperative context remains..

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Spinal Cord Protection for Open Descending Thoracic and Thoracoabdominal Aorta Surgery: Analysis of The Society of Thoracic Surgeons Adult Cardiac…

Abstract Background  (SCI) is a devastating complication of open descending thoracic (DTAA) and  (TAAA). We evaluated the efficacy of spinal drain placement on spinal injury in DTAA/TAAA repair. Methods Adult patients..

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Developing a physiological sciences network: advancing allied professions in cardiac sciences

Abstract Background Development of Physiological Science (PS) Networks in the United Kingdom is guided by a 2023 strategic framework aimed at enhancing diagnostic services and patient care through collaboration and..

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Large Single-Center Experience With Extubation During Neonatal and Pediatric Extracorporeal Membrane Oxygenation

Abstract Extubation of select neonatal and pediatric patients supported with extracorporeal membrane oxygenation (ECMO) may avoid ventilator-induced lung injury, decrease neurosedative exposure, and improve rehabilitation. A single-center retrospective cohort study..

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Extracorporeal Cytokine Adsorption in Sepsis: Current Evidence and Future Perspectives

Abstract Background: Sepsis and septic shock are major contributors to global morbidity and mortality. The “cytokine storm,” a hyper-inflammatory response, plays a central role in sepsis pathophysiology, leading to multi-organ..

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Extracorporeal Life Support in Pregnancy: A Systematic Review

Abstract Background The use of extracorporeal life support (ECLS) has expanded to include unique populations such as peripartum women. This systematic review aims to (1) quantify the number of cases..

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Guideline on pregnant and peripartum extracorporeal membrane oxigenation, Elso 2025 Narrative

At the time of publication of this guideline, the leading causes of maternal death for pregnant and peripartum patients include hemorrhage, infection, eclampsia, thromboembolism, and cardiac disease. Not only are these..

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