Yearly Archives: 2025

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Clinical application and research progress of platelet-rich plasma

Abstract Objective This systematic review aims to evaluate the extensive application of platelet-rich plasma (PRP) as a novel autologous cell therapy across various clinical disciplines in recent years. Method A..

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Cardiovascular effects of hyperoxia during and after cardiac surgery

Abstract During and after cardiac surgery with cardiopulmonary bypass, high concentrations of oxygen are routinely administered, with the intention of preventing cellular hypoxia. We systematically reviewed the literature addressing the..

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Evolving perspectives on blood transfusion in obstetric hemorrhage: a narrative review

Abstract Globally, postpartum hemorrhage is still among the most significant factors in preventable maternal morbidity and mortality. Although early recognition and intervention have improved with advances in obstetric care, transfusion..

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Are respiratory risks after cardiac surgery universal? A case study from Tuzla, Bosnia and Herzegovina

Abstract Objective Postoperative respiratory complications (PRCs) are a significant concern after cardiac surgery, contributing to increased morbidity and mortality. This study aimed to analyze the incidence and risk factors for..

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Hemodynamics in femoro-femoral venovenous extracorporeal membrane oxygenation using large eddy simulations

Abstract Venovenous extracorporeal membrane oxygenation (ECMO) is used for support in refractory severe respiratory failure. Venous drainage and return are accomplished through cannulation of patient’s major veins, typically on the..

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Understanding the Outcomes of Extracorporeal Membrane Oxygen Support in Patients With Sickle Cell Trait

Abstract The impact of common hemoglobinopathies, such as sickle cell trait (SCT), on outcomes in adults requiring extracorporeal membrane oxygenation (ECMO) remains understudied. Extracorporeal Life Support Organization registry data was..

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Vaccination as a new form of cardiovascular prevention: a European Society of Cardiology clinical consensus statement: With the contribution of…

Abstract Vaccination is increasingly acknowledged as an effective preventive measure not only against specific infections, but also for the prevention of cardiovascular disease in high-risk patients. Specifically, a growing body..

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Cue Detection and Self-Debriefing Techniques in Virtual Simulation: Techniques Using Cognitive Engineering Inspired Expertise Development Approaches

Abstract Introduction  Online experiential learning can benefit learners with scalable techniques to self-debrief and to develop cognitive skills in recognizing clinical cues. Methods  We developed techniques for cue-detection exercises and..

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Effect of Ciprofol on Postoperative Cognitive Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial

Abstract Purpose: To investigate the effects of ciprofol on postoperative cognitive function in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Patients and Methods: A total of 138 patients who underwent cardiac..

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Influence of High-Dose Heparin on CT EXTEM of ROTEM Sigma and ROTEM Delta During Cardiopulmonary Bypass

Abstract Transfusion management during cardiac surgery is commonly guided by algorithms using viscoelastic tests such as Rotational Thromboelastometry (ROTEM). Recently, the ROTEM Sigma, a new device developed as a fully..

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Buttock ischemia in adults with femoral venoarterial-extracorporeal membranoxygenation – A single center experience

Abstract Introduction Femoral veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is used as an ultima ratio to maintain circulation in patients with refractory cardiorespiratory failure, but is also associated with vascular and..

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A silicon membrane microfluidic oxygenator for use as an artificial placenta with minimal anticoagulation

Abstract Extreme prematurity carries a high burden of morbidity and mortality. The artificial placenta is an emerging therapy that has the potential to improve outcomes in these patients. However, current..

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Inadequate Oxygen Delivery During Cardiopulmonary Bypass Drives Inflammatory Reaction after Cardiac Surgery

Abstract Objectives Systemic inflammatory response syndrome (SIRS) is a common complication following cardiopulmonary bypass (CPB), associated with increased mortality. We assessed the relationship between indexed oxygen delivery (DO2i) during CPB..

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Uncovering digital overdiagnosis – Quantification and mitigation using clinical trajectories: Heparin-induced thrombocytopenia use case

Abstract Objective Overdiagnosis occurs when abnormalities meeting diagnostic criteria would remain asymptomatic if undiagnosed. Cases initially identified through digital diagnostic tools but later recognised as overdiagnosis are referred to as..

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Evaluation of the impact of extracorporeal membrane oxygenation (ECMO) oxygenator shunt flow on neonatal hemolysis: An in vitro study

Abstract Introduction Extracorporeal membrane oxygenation (ECMO) is utilized in critically ill neonates with severe cardiopulmonary failure. Hemolysis is a potential complication and is associated with significantly increased morbidity and mortality...

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Complications of microaxial flow pump and VA-ECMO in infarct-related cardiogenic shock: Insights from the Netherlands heart registration

Abstract Background Active mechanical circulatory support (MCS) is associated with high complication rates. Reducing device-related complications may improve outcomes in patients with infarct-related cardiogenic shock (AMI-CS). This study aims to..

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VV ECMO cannulation in infants and children under 10 kg: Evolving strategies, outcomes, and innovations

Abstract Venovenous extracorporeal membrane oxygenation (VV ECMO) has become an increasingly preferred modality for respiratory support in neonates and infants under 10 kg, driven by a growing recognition of its..

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Rescue Therapy With Factor VII for Refractory Cardiac Surgical Bleeding: A Propensity-Score-Matched Study

Abstract Objectives To compare effectiveness and safety of rescue therapy approach with recombinant Factor VII activated (rFVIIa) for refractory bleeding in cardiac surgery compared with a propensity-score-matched control group at..

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Baseline characteristics and in-hospital mortality predictors in female patients on venovenous extracorporeal membrane oxygenation: Impact of pregnancy

Abstract Background Venovenous extracorporeal membrane oxygenation (VV-ECMO) is often used for lung rest in critically ill patients, including pregnant patients. Objectives We aimed to determine how pregnant and non-pregnant patients..

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Predicting Successful Weaning from Veno-Arterial ECMO Using Machine Learning

Abstract Extracorporeal Membrane Oxygenation (ECMO) is a life-saving cardiopulmonary support for patients with acute heart failure. However, the process of weaning from veno-arterial (V-A) ECMO remains complex and risky. We..

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Simulation-Based Education for Extracorporeal Membrane Oxygenation and Strategies for Implementation

Abstract Simulation-based education (SBE) in health care is expanding in both scope and relevance. As on-the-job training is challenging in extracorporeal membrane oxygenation (ECMO), SBE features strongly in its curricula,..

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Machine learning in predicting preoperative intra-aortic balloon pump use in patients undergoing coronary artery bypass grafting

Abstract Background Intra-aortic balloon pump (IABP) implantation in the perioperative period of cardiac surgery is an auxiliary treatment for cardiogenic shock. However, there is a lack of effective prediction models..

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ELSO 2025 Narrative Guideline on the Use of ECMO for Accidental Hypothermia

Background Accidental hypothermia (AH) can be caused by exposure to cold weather conditions, immersion in water, avalanche burial in snow, or indoors, mostly affecting elderly patients with multiple comorbidities., There are..

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Clinical outcomes of levosimendan administration in veno-arterial extracorporeal membrane oxygenation: a meta-analysis

Abstract Objectives To evaluate the effectiveness of levosimendan in promoting weaning from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with refractory cardiogenic shock through a meta-analysis of clinical trials. Design Systematic review..

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A randomised clinical trial of regional cerebral perfusion versus deep hypothermic circulatory arrest: five-year and ten-year follow-up for neurodevelopmental outcomes…

Abstract Objective:This study aimed to evaluate school-age neurodevelopmental outcomes among children with single ventricle heart disease who underwent neonatal Norwood operation with regional cerebral perfusion compared to deep hypothermic circulatory..

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Decreased renal or cerebral oxygen saturation increases the risk of cardiac surgery-associated acute kidney injury in adult patients: a prospective…

Abstract Objective To determine the relationship between intraoperative decreased renal and cerebral oxygen saturation, as measured using near-infrared spectroscopy (NIRS), and cardiac surgery-associated acute kidney injury (CSA-AKI) in adults. Methods..

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Outcomes of a Second Run of Extracorporeal Membrane Oxygenation in Neonates: A Propensity Score Matched Analysis of a Nationwide Registry

Abstract This study analyzed the outcomes of neonates undergoing a second run of extracorporeal membrane oxygenation (ECMO) to determine whether there is a benefit to a repeated run. We used..

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Selective Cytopheretic Device Therapy in the Context of Extracorporeal Membrane Oxygenation

Abstract This review examines the clinical data and basic science research to evaluate the potential of the Selective Cytopheretic Device (SCD) in mitigating Extracorporeal Membrane Oxygenation (ECMO)-associated inflammation. In brief,..

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Pre-bypass ultrafiltration reduces cytokine burden of blood prime in pediatric cardiac surgery

Abstract Allogeneic red blood cells (RBCs) are commonly used for cardiopulmonary bypass (CPB) circuit priming in congenital heart surgery. While convection-based pre-bypass ultrafiltration (PBUF) corrects acid–base, electrolyte, and metabolite imbalances,..

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Decoding long COVID-associated cardiovascular dysfunction: Mechanisms, models, and new approach methodologies

Abstract The COVID-19 pandemic has revealed that the impact of SARS-CoV-2 infection extends well beyond the acute phase, with long-term sequelae affecting multiple organ systems, most notably, the cardiovascular system...

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