Yearly Archives: 2024

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Myocardial protection in cardiac surgery: a comprehensive review of current therapies and future cardioprotective strategies

Abstract Cardiac surgery with cardiopulmonary bypass results in global myocardial ischemia–reperfusion injury, leading to significant postoperative morbidity and mortality. Although cardioplegia is the cornerstone of intraoperative cardioprotection, a number of..

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Comparative analysis of oxygenator dysfunction in polymethylpentene oxygenators: A pilot study

Abstract Introduction Polymethylpentene (PMP) oxygenators serve as the primary oxygenator type utilized for ECMO. With the number of PMP oxygenators available, it has become increasingly important to determine differences among..

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Controlled automated reperfusion of the whole body after cardiac arrest: Device profile of the CARL system

Abstract Background Cardiac arrest is associated with high mortality rates and severe neurological impairments. One of the underlying mechanisms is global ischemia-reperfusion injury of the body, particularly the brain. Strategies..

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The Impact of Acute Kidney Injury on Chronic Kidney Disease After Cardiac Surgery: A Systematic Review and Meta-analysis

Abstract Objectives To evaluate the impact of  on transition to chronic  (CKD) after cardiac surgery and to determine frequency of incident CKD in these patients. Design A  and meta-analysis of observational studies. Setting..

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Transoesophageal echocardiography in cardiac arrest: From the emergency department to the intensive care unit

Abstract Cardiac arrest is a hyper-acute condition with a high mortality that requires rapid diagnostics and treatment. As such, point-of-care ultrasound (POCUS) has become a valuable tool in the assessment..

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Global Perfusion Practice Survey: Readiness of On-Call and Emergency Operation Rooms

Abstract Introduction Perfusion safety in cardiac surgery is vital, and this survey explores perfusion practices, perspectives, and challenges related to it. Specifically, it examines the readiness of on-call and emergency..

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Blood Management: A Current Opportunity in Perioperative Medicine

Abstract The purpose of this viewpoint is to provide awareness of the current opportunities to enhance a high-value care approach to blood product transfusion. It provides a historical context to..

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Innovations in protective mechanical ventilation for acute respiratory distress syndrome management

Introduction Managing acute respiratory distress syndrome (ARDS) poses significant challenges due to its heterogeneous nature. As of 2024, the updated global definition of ARDS now includes patients receiving noninvasive ventilation..

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The Nephroprotective Effect of Nitric Oxide during Extracorporeal Circulation: An Experimental Study

Abstract This study aims to determine the effectiveness of administering 80 ppm nitric oxide in reducing kidney injury, mitochondrial dysfunction and regulated cell death in kidneys during experimental perfusion. Twenty-four..

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Pulmonary hypertension in heart failure: the good, the bad, and the ugly

Abstract Pulmonary hypertension (PH) is a frequent condition in patients with heart failure (HF), which complicates the course of the HF syndrome. Irrespective of left ventricular ejection fraction (LVEF), PH is..

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Intra-Aortic Balloon Pump

Introduction Patients with the clinical and biochemical signs and symptoms of hypoperfusion secondary to cardiac failure or cardiac arrest carry high short-term mortality. Various mechanical circulatory devices have been developed to..

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Should Obesity Be an Exclusion Criterion for Extracorporeal Membrane Oxygenation Support? A Scoping Review

Abstract Obesity is often considered a contraindication to extracorporeal membrane oxygenation (ECMO) candidacy due to technical challenges with vascular access, higher cardiac output requirements, and known associations between obesity and..

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How to be a good mentor

My background as a mentor To provide some context to my involvement in this discussion and to outline my foundation in mentorship, I would like to offer a brief overview..

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Organ Donation from Patients Receiving Extracorporeal Membrane Oxygenation: A Systematic Review

Abstract Objective The mismatch between the demand for and supply of organs for transplantation is steadily growing. Various strategies have been incorporated to improve the availability of organs, including organ..

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The American Association for Thoracic Surgery (AATS) 2024 expert consensus document: Management of neonates and infants with Ebstein anomaly

Abstract Objectives Symptomatic neonates and infants with Ebstein anomaly (EA) require complex management. A group of experts was commissioned by the American Association for Thoracic Surgery to provide a framework..

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Designing an experimental method for assessing biocompatibility of circuit coatings using biomarkers for platelet activation during cardiopulmonary bypass

Abstract Introduction: Cardiopulmonary bypass is an essential component of cardiothoracic surgeries. However, significant complications such as systemic inflammatory response syndrome (SIRS) resulting from cardiopulmonary bypass (CPB) are a common occurrence..

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Update on perioperative fluids ( pediatrie)

Abstract Adequate fluid management in the  in paediatric patients is essential for restoring and maintaining homeostasis and ensuring adequate . A well-designed infusion regimen is crucial for preventing severe complications such as hyponatraemic encephalopathies...

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Extracorporeal Life Support in Cardiogenic Shock Complicating Acute Myocardial Infarction

Abstract Despite multimodal treatment of patients with  (CS) complicating  (AMI), the outcome remains poor. Large retrospective analyses and animal models suggest that  (ECLS) in CS-complicating AMI improves outcome . However, to date, no  assessing the..

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Venoarterial Extracorporeal Membrane Oxygenation for Cardiopulmonary Support: Insights From a German Registry

Abstract Venoarterial extracorporeal membrane oxygenation (VA-ECMO) support is a lifesaving tool in cardiovascular care, providing excellent hemodynamic assistance for numerous indications, such as cardiogenic shock or periprocedural support in patients..

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Non-invasive prediction of massive transfusion during surgery using intraoperative hemodynamic monitoring data

Abstract Objective Failure to receive prompt  leads to severe complications if massive  occurs during surgery. For the timely preparation of blood products, predicting the possibility of massive transfusion (MT) is essential to..

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Effect of haemoadsorption during cardiac surgery for Staphylococcus aureus endocarditis: a REMOVE trial post hoc analysis Get access Arrow

Abstract OBJECTIVES Multi-organ failure is one of the leading causes of mortality after cardiac surgery for infective endocarditis (IE). Although the randomized evidence does not support the use of haemoadsorption..

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Outcomes associated with absent blood product utilization in Jehovah’s witness patients compared to the standard of care in cardiac surgery:…

Abstract Introduction For Jehovah’s Witness (JW) patients requiring cardiac surgery, various strategies such as preoperative use of erythropoietin stimulating agents (ESAs), intravenous iron (IVI), and non-pharmacologic interventions have emerged to..

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Mechanical Ventilation During Extracorporeal Membrane Oxygenation: Getting the Oxygenation Right

Abstract We read with great interest Pavlov’s letter to the editor on oxygenation targets and optimization of mechanical ventilation (MV) during extracorporeal membrane oxygenation. Adding FiO2 titration strategy would have been..

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Rethinking Coagulation Activation during Extracorporeal Membrane Oxygenation: Insights from the Case of Mr. Hageman

Abstract Blood surface interfacing that occurs within the extracorporeal membrane oxygenation (ECMO) circuit initiates contact activation, an important hemostatic pathway initiated by the Hageman factor, also called factor XII. Factor..

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Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis

Abstract Purpose Veno-arterial extracorporeal life support (ECLS) is increasingly used in patients during cardiac arrest and cardiogenic shock, to support both cardiac and pulmonary function. We performed a systematic review..

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Prevalence and Survival of Prolonged Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome: An Analysis of the Extracorporeal Life…

Abstract OBJECTIVES:  To examine trends in utilization and outcomes among patients with the acute respiratory distress syndrome (ARDS) requiring prolonged venovenous extracorporeal membrane oxygenation (VV ECMO) support. DESIGN:  Retrospective observational..

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Unloading in cardiogenic shock: the rationale and current evidence

Abstract Purpose of review  Discussing the rationale and current evidence for left ventricular unloading in cardiogenic shock. Recent findings  Microaxial flow pumps (MFP) and intra-aortic balloon pumps (IABP) augment cardiac..

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Design and principle of operation of the HeartMate PHP (percutaneous heart pump)

Abstract The HeartMate PHP (percutaneous heart pump) is a second-generation transcatheter axial flow circulatory support system. The collapsible catheter pump is inserted through a 14 Fr sheath, deployed across the..

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