Yearly Archives: 2021

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Lab-created Heart Valves Can Grow With the Patient

  March 18, 2020 — A groundbreaking new study led by University of Minnesota Twin Cities researchers from both the College of Science and Engineering and the Medical School shows..

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Le cœur artificiel Carmat est prêt à être commercialisé

Le cœur Carmat de l'entreprise du même nom a obtenu il y a peu  pour être commercialisé en Europe et dans certains pays qui acceptent ladite certification comme gage de qualité...

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The end of the unique myocardial band: Part I. Anatomical considerations

Abstract The concept of the ‘unique myocardial band’, which proposes that the ventricular myocardial cone is arranged like skeletal muscle, provides an attractive framework for understanding haemodynamics. The original idea..

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The end of the unique myocardial band: Part II. Clinical and functional considerations

Abstract Two of the leading concepts of mural ventricular architecture are the unique myocardial band and the myocardial mesh model. We have described, in an accompanying article published in this..

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Diffusion-weighted imaging detects early brain injury after hypothermic circulatory arrest in pigs

Abstract OBJECTIVES Cerebral injury is a complication of surgery with deep hypothermic circulatory arrest (DHCA). This study aimed to evaluate diffusion-weighted imaging (DWI) for the early detection of brain injury..

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Predictive Factors of Long-Term Stay in the ICU after Cardiac Surgery: Logistic CASUS Score, Serum Bilirubin Dosage and Extracorporeal Circulation…

Abstract Objective: To test the capacity of the Logistic CASUS Score on the second postoperative day, the total serum bilirubin dosage on the second postoperative day and the extracorporeal circulation..

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Severity of hyperoxia as a risk factor in patients undergoing on-pump cardiac surgery

Abstract Background. Hyperoxia has long been perceived as a desirable or at least an inevitable part of cardiopulmonary bypass. Recent evidence suggest that it might have multiple detrimental effects on..

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Bivalirudin anticoagulation for left ventricular assist device implantation on an extracorporeal life support system in patients with heparin-induced thrombocytopenia antibodies

Abstract OBJECTIVES Heparin-induced thrombocytopenia (HIT) requires alternative anticoagulation strategies. We investigated outcomes in patients with HIT antibodies undergoing low-dose bivalirudin anticoagulation during left ventricular assist device implantation on an extracorporeal..

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Impact of minimally invasive extracorporeal circuits on octogenarians undergoing coronary artery bypass grafting. Have we been looking in the wrong…

Abstract OBJECTIVES Minimally invasive extracorporeal circuits (MiECCs) aim at the preservation of physiologic reserves, the impact of which is expected to be most evident in patients in whom these are..

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Fluid accumulation after closure of atrial septal defects: the role of colloid osmotic pressure

Abstract OBJECTIVES Following paediatric cardiac surgery with cardiopulmonary bypass (CPB), there is a tendency for fluid accumulation. The colloid osmotic pressure of plasma (COPp) and interstitial fluid (COPi) are determinants..

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Surgical treatment of postinfarction ventricular septal defect: risk factors and outcome analysis

Abstract OBJECTIVES Postinfarction ventricular septal defect is a serious mechanical complication of acute myocardial infarction associated with high postoperative mortality. The aim of this study was to review our experience..

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Population Pharmacokinetics and Pharmacodynamic Target Attainment of Meropenem in Critically Ill Young Children

Abstract OBJECTIVE This study aims to describe the population pharmacokinetics and pharmacodynamic target attainment of meropenem in critically ill children. METHODS The study involved a retrospective medical record review from..

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Management of Mechanical Ventilation During Extracorporeal Membrane Oxygenation

Abstract This chapter explores the best practices of mechanical ventilation during extracorporeal membrane oxygenation (ECMO) through a detailed discussion of the physiologic theory and clinical evidence. Future areas of study..

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The Use of Extracorporeal Circulation in Suspected Brain Dead Organ Donors with Cardiopulmonary Collapse

Abstract Donor shortage is a major limitation in organ transplantation. Several studies have reported that extracorporeal membrane oxygenation (ECMO)-assisted organ donation can be successfully completed without inducing warm ischemia in..

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Anesthetic Management of Patients on ECMO

Abstract The management of a patient placed on extracorporeal membrane oxygenation (ECMO) is a team effort. The anesthesiology team plays an integral part during cannulation and oftentimes as well during..

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Simulation Training on Extracorporeal Membrane Oxygenation

Abstract Conventional extracorporeal membrane oxygenation (ECMO) training usually only consists of didactic lectures and water drill of ECMO circuit. However, learners cannot “experience” changes of clinical condition of patients. Simulation-based..

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ECMO Biocompatibility: Surface Coatings, Anticoagulation, and Coagulation Monitoring

Abstract The interaction between the patient and the ECMO (extracorporeal membrane oxygenation) circuit initiates a significant coagulation and inflammatory response due to the large surface area of foreign material contained..

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Veno-arterial extracorporeal membrane oxygenation without therapeutic anticoagulation for intra-operative cardiopulmonary support during lung transplantation

Abstract Cardiopulmonary support is frequently required during lung transplantation. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has been recently shown to be an acceptable and, perhaps, safer alternative to cardiopulmonary bypass machine..

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Effect of acid–base balance on postoperative course in children with hypoplastic left heart syndrome after the modified Norwood procedure

Abstract Hypoplastic left heart syndrome (HLHS) is a congenital heart defect that requires 3-stage cardiac surgical treatment and multidirectional specialist care. The condition of newborns in the first postoperative days..

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Coronary Perfusion Pressure during Antegrade Cardioplegia in On-Pump CABG Patients

Abstract Objective: The aim of this study was to investigate whether aortic tension estimated by palpation and cardioplegia infusion line pressure provide results equivalent to those obtained with direct aortic..

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Influence of low-flow time on survival after extracorporeal cardiopulmonary resuscitation (eCPR)

Abstract Background Venoarterial extracorporeal membrane oxygenation (VA-ECMO) support under extracorporeal cardiopulmonary resuscitation (eCPR) is the last option and may be offered to selected patients. Several factors predict outcome in these..

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Different strategies for mechanical VENTilation during CardioPulmonary Bypass (CPBVENT 2014): study protocol for a randomized controlled trial

Abstract Background There is no consensus on which lung-protective strategies should be used in cardiac surgery patients. Sparse and small randomized clinical and animal trials suggest that maintaining mechanical ventilation..

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Predictors of intracranial hemorrhage in adult patients on extracorporeal membrane oxygenation: an observational cohort study

Abstract Background Intracranial hemorrhage (ICH) is a recognized complication of adults treated with extracorporeal membrane oxygenation (ECMO) and is associated with increased morbidity and mortality. However, the predictors of ICH..

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Mycobacterium chimaera: The ethical duty to disclose the minimal risk of infection to exposed patients

Abstract A recent study by Sommerstein and colleagues has demonstrated a causal link between Mycobacterium chimaera infection and the LivaNova PLC Stöckert 3T heater-cooler system (LivaNova PLC, London, United Kingdom) used in cardiac..

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Randomized trial of red cell washing for the prevention of transfusion-associated organ injury in cardiac surgery

Abstract Background.  Experimental studies suggest that mechanical cell washing to remove pro-inflammatory components that accumulate in the supernatant of stored donor red blood cells (RBCs) might reduce inflammation and organ..

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Neural network imaging to characterize brain injury in cardiac procedures: the emerging utility of connectomics

Abstract Cognitive dysfunction is a poorly understood but potentially devastating complication of cardiac surgery. Clinically meaningful assessment of cognitive changes after surgery is problematic because of the absence of a..

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Early and long-term cognitive outcome after conventional cardiac valve surgery

Abstract OBJECTIVES:  Adverse cognitive outcome is well recognized after coronary artery bypass grafting (CABG) while little is known about the extent and duration of decline after cardiac valve surgery. We..

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New dimensions for extracorporeal circulation

Abstract The overwhelming success of cardiac surgery is closely related to the development and use of extracorporeal perfusion. After the first successful treatment of a stab wound to the heart..

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Lung Transplantation and the Routine Use of Cardiopulmonary Bypass and Median Sternotomy: Experience at the Ochsner Multi-Organ Transplant Institute

Abstract Background: From 1990-2005 at Ochsner Medical Center in New Orleans, LA, cardiopulmonary bypass (CPB) was used only when necessary during lung transplantation surgeries. Ochsner's lung transplant program was closed..

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Spinal cord protection during thoracoabdominal aortic replacement: spinal cord perfusion maintenance

Abstract OBJECTIVES:  Spinal cord protection during thoracoabdominal aortic surgery is challenging for surgeons. We performed thoracoabdominal replacement using a strategy for maintaining spinal cord perfusion pressure. Here, we report our..

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