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Management of Amniotic Fluid Embolism (AFE) using anticoagulation-free ECMO

Abstract Amniotic fluid embolism (AFE) is a critical obstetric complication characterized by the entry of amniotic fluid and its components into maternal circulation during parturition, leading to acute cardiopulmonary failure,..

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ECMO in Pregnancy: Analysis of Indications, Management and Outcomes

Abstract Extracorporeal membrane oxygenation (ECMO) has become a critical rescue therapy for pregnant and peripartum patients experiencing life-threatening cardiac or respiratory failure that is refractory to standard treatments. Pregnancy induces..

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Optimizing Extracorporeal Membrane Oxygenation Gas Exchange: Key Insights for Clinical Management

Abstract This review examines the role of extracorporeal membrane oxygenation (ECMO) in the management of severe acute respiratory distress syndrome (ARDS), emphasizing its contribution to lung-protective ventilation through optimizing oxygenation..

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Effectiveness and safety of bivalirudin anticoagulation therapy in adult patients receiving extracorporeal membrane oxygenation: A systematic review and meta-analysis

Abstract Background:  Compared to heparin, there is limited evidence of the benefits of bivalirudin in the patients with extracorporeal membrane oxygenation (ECMO). Methods:  We searched for studies comparing bivalirudin anticoagulation..

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Von Willebrand factor in Ecmo: a dynamic modulator of hemorrhage and thrombosis

Abstract Von Willebrand factor (vWF) orchestrates hemostasis through platelet activation, factor VIII stabilization, and inflammatory modulation, with emerging evidence highlighting its shear-dependent conformational dynamics as a critical regulator of thrombus..

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Cell-free hemoglobin is associated with microcirculatory perfusion disturbances and acute kidney injury in rats on extracorporeal membrane oxygenation

Abstract Background Extracorporeal membrane oxygenation (ECMO) is a life-saving treatment, but carries a high risk of complications such as acute kidney injury (AKI). A contributor to AKI is hemolysis, which..

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Liberal or restrictive transfusion for veno-arterial extracorporeal membrane oxygenation patients: a target trial emulation using the OBLEX study data

Abstract Background The optimal transfusion threshold for patients undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO) remains uncertain. Methods We used data from OBLEX (ClinicalTrials.gov: NCT03714048), an international, prospective, observational study conducted..

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Survival After Amniotic Fluid Embolism and Extracorporeal Membrane Oxygenation Support

Abstract Background Amniotic fluid embolism is a rare potential complication in the peripartum period. Case Summary A 27-year-old nulliparous woman presented for elective induction at 41 weeks' gestation. Due to..

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Prone positioning and bleeding risk during extracorporeal membrane oxygenation in severe ARDS patients

Abstract Purpose To assess whether prone positioning (PP) increases bleeding risk compared to supine positioning in ARDS patients undergoing veno venous Extracorporeal Membrane Oxygenation (VV ECMO). Materials and Methods A..

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Investigating optimal drainage cannula for venovenous extracorporeal membrane oxygenation: impact of side holes on blood oxygenation – an in vitro…

Abstract Venovenous extracorporeal membrane oxygenation (VV ECMO) relies on effective blood drainage, and cannula design plays a crucial role in optimizing blood oxygenation. Recirculation, where oxygenated blood returns to the..

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A Miniaturized Centrifugal Pump ECMO System Enhances Hemocompatibility in Small Animal Models

Abstract Extracorporeal membrane oxygenation (ECMO) is a fundamental treatment for cardiovascular and severe pulmonary diseases, with small animal models providing critical insights into organ protection during cardiopulmonary bypass and ECMO..

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The impact of antithrombin III supplementation on prognosis during extracorporeal membrane oxygenation: a systematic review and meta-analysis

Abstract Extracorporeal membrane oxygenation (ECMO) is a mechanical circulatory and respiratory support system that facilitates gas exchange and hemodynamic stabilization through an external circuit. ECMO has been increasingly utilized for..

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Extracorporeal Membrane Oxygenation in Pregnancy: An Analysis of the Extracorporeal Life Support Organization Registry

Abstract Objectives:  We examined data from the International Registry of the Extracorporeal Life Support Organization to identify risk factors for mortality in pregnant and peripartum patients receiving extracorporeal membrane oxygenation...

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Impact of Venoarterial Extracorporeal Membrane Oxygenation on Hemodynamics and Cardiac Mechanics: Insights From Pressure-Volume Loop Analysis

Abstract Venoarterial extracorporeal membrane oxygenation (VA-ECMO) serves as a critical mechanical circulatory support modality, sustaining systemic circulation in cases of severe cardiac failure or cardiac arrest. While VA-ECMO improves hemodynamics,..

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Nutritional support in pediatric patients with extracorporeal membrane oxygenation: new insights

Abstract Nutritional support in pediatric patients receiving extracorporeal membrane oxygenation (ECMO) therapy is controversial. Although ECMO is increasingly used in pediatric intensive care units, there is no consensus on the..

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Is it Time to Upgrade Neuromonitoring in ECPR Recipients to Evaluate Cerebral Perfusion Imbalances Adequately?

Abstract Veno-arterial extracorporeal membrane oxygenation (ECMO) brings many monitoring pitfalls due to the countercurrent blood flow, which may create left ventricular overload and perfusion imbalances between the two cerebral hemispheres...

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Exploring the Association Between Early PaCO2 Correction Speed and Cerebrovascular Autoregulation in a Porcine Model of Extracorporeal Resuscitation

Abstract Background Prior clinical research demonstrated that rapid reduction in arterial carbon dioxide (PaCO2) levels during extracorporeal membrane oxygenation (ECMO) is associated with acute brain injury (ABI), which may be..

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Physiological and clinical effects of two ultraprotective ventilation strategies in patients with veno-venous extracorporeal membrane oxygenation: the ECMOVENT study

Abstract Purpose The optimal ventilation strategy in acute respiratory distress syndrome (ARDS) patients with veno-venous extracorporeal membrane oxygenation (VV-ECMO) remains unknown. We aimed to compare the effects of two ultra-protective..

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Extracorporeal Life Support in Pregnancy: A Systematic Review

Abstract Background The use of extracorporeal life support (ECLS) has expanded to include unique populations such as peripartum women. This systematic review aims to (1) quantify the number of cases..

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Guideline on pregnant and peripartum extracorporeal membrane oxigenation, Elso 2025 Narrative

At the time of publication of this guideline, the leading causes of maternal death for pregnant and peripartum patients include hemorrhage, infection, eclampsia, thromboembolism, and cardiac disease. Not only are these..

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Endothelial Activation and Permeability in Patients on VV-ECMO Support: An Exploratory Study

Abstract Background Veno-venous extracorporeal membrane oxygenation (VV-ECMO) supports critically ill patients with respiratory failure. However, ECMO may induce systemic inflammation, hemolysis, and hemodilution, potentially resulting in endothelial activation and damage. Therefore,..

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An initiative to reduce blood stream infections (BSI) in patients on ECMO

Abstract Introduction Blood Stream Infections (BSI) occur in 3-35% of patients on ECMO (Extracorporeal membrane Oxygenation). With the increased use of ECMO since the COVID-19 pandemic, the magnitude of this..

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Single venous cannulation for bi-atrial venoarterial extracorporeal membrane oxygenation in bridge to transplantation: a two-in-one approach

Abstract Venoarterial extracorporeal membrane oxygenation (VA-ECMO) often leads to left ventricular (LV) overload, particularly in patients with biventricular cardiogenic shock. This increased afterload can hinder cardiac muscle recovery and cause..

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Activated Clotting Time and Haemostatic Complications in Patients Receiving ECMO Support: A Systematic Review

Abstract Background: Extracorporeal membrane oxygenation (ECMO) requires systemic anticoagulation to prevent clotting, typically using unfractionated heparin (UFH). However, anticoagulation carries a bleeding risk, necessitating monitoring. Activated clotting time (ACT) is..

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Global Survey of Extracorporeal Membrane Oxygenation Transport Programs: Variability in Team Composition, Training, and Capabilities

Abstract Extracorporeal membrane oxygenation (ECMO) is a form of cardiopulmonary support associated with improved survival in severe respiratory failure and refractory cardiac arrest. Extracorporeal membrane oxygenation is highly specialized and..

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Prognostic scores of extracorporeal membrane oxygenation: a scoping review

Abstract BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is an effective measure for saving the lives of critically ill patients. Prompt identification of the risk factors for mortality among patients receiving ECMO and..

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Re-evaluating the association between thrombocytopenia and bleeding in extracorporeal membrane oxygenation (ECMO)

Abstract Objectives The platelet trigger at which to transfuse platelets to prevent bleeding complications in patients supported with extracorporeal membrane oxygenation (ECMO) is unclear. We aimed to elucidate the association..

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Impact of Preoperative Extracorporeal Membrane Oxygenation Use on Lung Transplant Outcomes

Abstract Background  (ECMO) may be used to support critically ill patients before . The relationship between preoperative venoarterial and venovenous ECMO and their relationship with  indications remain poorly elucidated. Methods This study..

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Venovenous Extracorporeal Membrane Oxygenation Cannulation by Intensivists and Surgeons: A Single-Center Retrospective Noninferiority Analysis of Complications and Outcomes From 2018…

Abstract Objectives:  To evaluate the safety and efficacy of venovenous extracorporeal membrane oxygenation (ECMO) cannulation by nonsurgeon intensivists (critical care medicine intensivists [CCM]) compared with cardiothoracic surgeons (CTS). Design:  Retrospective,..

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In-Hospital Outcomes and Readmissions in High-Risk Pulmonary Embolism Patients Requiring Extracorporeal Membrane Oxygenation Support

Abstract There are limited data on the use of extracorporeal membrane oxygenation (ECMO) in high-risk pulmonary embolism (PE) patients. We analyzed the use of ECMO in high-risk PE patients (defined..

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