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Association of genetic polymorphisms with acute kidney injury after cardiac surgery in a Southeast Asian population

Abstract Introduction Genetic polymorphisms are important in explaining the wide interpatient variability that exists in the development of acute kidney injury (AKI) post cardiac surgery. We hypothesised that polymorphisms in..

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Associations of nadir haemoglobin level and red blood cell transfusion with mortality and length of stay in surgical specialties: a…

Abstract Summary Few studies have investigated if, and how, red cell transfusion and anaemia interact. We analysed 60,955 admissions to three metropolitan hospitals in Western Australia between 2008 and 2017..

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Carbon dioxide removal using low bicarbonate dialysis in rodents

Abstract Background: Extracorporeal carbon dioxide removal may be used to manage hypercapnia, but compared to dialysis, it’s not widely available. A recent in vitro study showed that dialysis with low bicarbonate dialysates..

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Aprotinin versus tranexamic acid in children undergoing cardiac surgery: an observational study

Abstract OBJECTIVES: The upcoming release of aprotinin in paediatric cardiac surgery prompted a re-evaluation of its use in comparison to tranexamic acid (TXA) focusing on their effect on exposure to..

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Rescue of Discarded Grafts for Liver Transplantation by Ex Vivo Subnormothermic and Normothermic Oxygenated Machine Perfusion: First Experience in Spain

Abstract Background   (MP) has been reported as a possibly method to rescue discarded organs. The main aim of this study was to report an initial experience in Spain using MP..

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Preoperative pulmonary function in all comers for cardiac surgery predicts mortality

Abstract OBJECTIVES Although reduced lung function and chronic obstructive pulmonary disease (COPD) is associated with higher risk of death following cardiac surgery, preoperative spirometry is not performed routinely. The aim..

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Hemolytic characteristics of three suctioning systems for use with a newly developed cardiopulmonary bypass system

Abstract Introduction: We have been developing a closed-circuit cardiopulmonary bypass (CPB) system (“Dihead CPB”) for application during coronary artery bypass grafting (CABG) and valve surgery. To strive for minimal hemolysis..

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Perioperative intraperitoneal metabolic markers in patients undergoing cardiac surgery with cardiopulmonary bypass: an exploratory pilot study

Abstract Background: Cardiopulmonary bypass and postoperative cardiac dysfunction cause splanchnic hypoperfusion resulting in intra-abdominal anaerobic metabolism and risk for gastrointestinal complications. The intra-abdominal metabolism can be monitored by intraperitoneal measurement..

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Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery

Abstract BACKGROUND Volatile (inhaled) anesthetic agents have cardioprotective effects, which might improve clinical outcomes in patients undergoing coronary-artery bypass grafting (CABG). METHODS We conducted a pragmatic, multicenter, single-blind, controlled trial..

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Domain‐specific cognitive dysfunction after cardiac surgery. A secondary analysis of a randomized trial

Abstract Background Brain injury and cognitive dysfunction are serious complications after cardiac surgery. In the perfusion pressure cerebral infarcts (PPCI) trial, we allocated cardiac surgery patients to a mean arterial..

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Accuracy of blood glucose measurements using the NOVA StatStrip® glucometer during cardiac surgery: a prospective observational study

Abstract Purpose The Nova StatStrip® Glucose Hospital Meter System (Nova Biomedical, Waltham, MA, USA) is United States Food and Drug Administration approved for point-of-care use in critically ill patients, but..

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Reduced re-exploration and blood product transfusion after the introduction of the Papworth haemostasis checklist

Abstract OBJECTIVES Between 2% and 8% of patients return to the theatre for mediastinal bleeding following cardiac surgery. In the majority of patients, a surgical source of bleeding is identified...

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Anticoagulation during ECMO in neonatal and paediatric patients

Abstract  (ECMO) is a form of  (ECLS) which is used frequently in the paediatric and neonatal setting to support either the pulmonary, or both the pulmonary and . Management of ECMO requires..

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Platelet Contribution to Clot Strength in Thromboelastometry: Count, Function, or Both?

Abstract In thromboelastometry (ROTEMTM) the difference in amplitude between the EXTEM and the FIBTEM is considered an index of platelet contribution to clot strength (PCSamp). The difference in elasticity (PCSel)..

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Correlation of cardiopulmonary bypass duration with acute renal failure after cardiac surgery

Abstract Objectives Prolonged  (CPB) is recognized as a risk factor for  (ARF), but the dose effect of time on bypass is unknown. We therefore examined the risk of ARF associated with increasing..

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Acute kidney injury and fluid overload in infants and children after cardiac surgery

Abstract Acute kidney injury is a common and serious complication after congenital heart surgery, particularly among infants. This comorbidity has been independently associated with adverse outcomes including an increase in..

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Recent Advances in Congenital Heart Surgery: Alternative Perfusion Strategies for Infant Aortic Arch Repair

Abstract Purpose of Review This paper will discuss current cannulation strategies for infant aortic arch repair and compare them to more traditionally used techniques. Recent Findings Aortic arch reconstruction in..

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The effect of high-dose nitroglycerin on the cerebral saturation and renal function in cardiac surgery

Abstract Background:  The aim of the study was to evaluate the effects of high-dose nitroglycerine administered during cardiopulmonary bypass on the intraoperative cerebral saturation and postoperative serum creatinine concentration in..

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Almost-certain malignant hyperthermia during cardiopulmonary bypass: a case report and literature review

Abstract Malignant hyperthermia is a well-known but potentially lethal disorder which is triggered by volatile anesthetics and depolarizing muscle relaxants. Early diagnosis and treatment could save lives. However, during cardiac..

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Extracorporeal Membrane Oxygenation Appropriateness: An Interdisciplinary Consensus-Based Approach

Abstract We describe a quality improvement initiative aimed at achieving interdisciplinary consensus about the appropriate delivery of extracorporeal membrane oxygenation (ECMO). Interdisciplinary rounds were implemented for all patients on ECMO..

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Extracorporeal Cardiopulmonary Resuscitation: One-Year Survival and Neurobehavioral Outcome Among Infants and Children With In-Hospital Cardiac Arrest

Abstract Objective:  To describe neurobehavioral outcomes and investigate factors associated with survival and survival with good neurobehavioral outcome 1 year after in-hospital cardiac arrest for children who received extracorporeal cardiopulmonary..

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Pediatric out-of-hospital cardiac arrest: Time to goal target temperature and outcomes

Abstract Aim Although recent  (CA) trials found no benefits of  versus normothermia , preclinical models suggest earlier timing of hypothermia improves  efficacy. This study investigated whether shorter time to goal temperature was associated with..

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Intravenous amino acid therapy for kidney protection in cardiac surgery patients: A pilot randomized controlled trial

Abstract Objective To determine whether a continuous  of standard amino acids could preserve kidney function after on-pump cardiac surgery. Methods Adult patients scheduled to receive cardiac surgery lasting longer than 1 hour..

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Postoperative Acute Kidney Injury in Young Adults With Congenital Heart Disease

Abstract Background There is an increasing number of young adults living with  (CHD). The goal of this study was to ascertain the frequency of  (AKI) as well as the risk factors and..

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Intraoperative infusion of noradrenaline improves platelet aggregation in patients undergoing coronary artery bypass grafting: a randomized controlled trial

Abstract Essentials Strategies to improve platelet function may reduce excessive bleeding during cardiac surgery. Patients were randomized to standard care or standard care + noradrenaline infusion. Low‐dose noradrenaline improved intraoperative..

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Trends and Updates on Cardiopulmonary Bypass Setup in Pediatric Cardiac Surgery

Abstract Perfusion strategies for  have direct consequences on pediatric cardiac surgery outcomes. However, inconsistent study results and a lack of uniform evidence-based guidelines for pediatric cardiopulmonary bypass management have led to..

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Real Age: Red Blood Cell Aging During Storage

Abstract Background During cold storage, some red blood cell (RBC) units age more rapidly than others. Yet, the Food and Drug Administration has set a uniform storage limit of 42..

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Outcomes after extracorporeal life support for postcardiotomy cardiogenic shock

Abstract Background and Aim of the Study Extracorporeal life support (ECLS) may be necessary in refractory postcardiotomy cardiogenic shock (PCS) unresponsive to optimal medical treatment. We sought to analyze the..

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Three consecutive cases of fatal intraoperative intracardiac thrombosis associated with the initiation of venoarterial extracorporeal membrane oxygenation in the presence…

Abstract Central venoarterial extracorporeal membrane oxygenation has been used since the 1970s to support patients with cardiogenic shock following cardiac surgery. Despite this, in-hospital mortality is still high, and although..

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