Perfusfind S.L.
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Case report: Intraoperative thrombosis cardiac arrest in extended right hepatectomy involving use of local haemostatic agent in intraoperative cell salvage…

Abstract Introduction In modern surgical era, local haemostatic agents and blood components such as recombinant activated factor VII (rFVIIa) have expanded surgeons’ armamentarium in controlling “surgical” and “nonsurgical bleeding”. We..

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The effect of sleep deprivation and disruption on DNA damage and health of doctors

Summary Observational studies have highlighted the detrimental health effects of shift work. The mechanisms through which acute sleep deprivation may lead to chronic disease have not been elucidated, but it..

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Factors involved in initiation and regulation of complement lectin pathway influence postoperative outcome after pediatric cardiac surgery involving cardiopulmonary bypass

Abstract Congenital heart disease (CHD) often requires surgical intervention, and is sometimes associated with life-threatening post-operative complications. We have investigated some factors of the innate immune system involved in the..

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Comparison of intestinal ischemia after on-pump versus off-pump coronary artery bypass grafting surgery

Abstract Acute mesenteric ischemia (AMI), one of the gastrointestinal system complications, which occurs following cardiac surgery, is challenged in the literature with a diminished incidence of AMI by heart surgery..

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Effect of high- versus low-volume saline administration on acute kidney injury after cardiac surgery

Abstract Background: Fluid resuscitation is critical to perioperative maintenance of adequate preload and cardiac output after cardiac surgery. Liberal use of saline, however, is reportedly associated with an increased risk of..

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Shifts of Transfusion Demand in Cardiac Surgery After Implementation of Rotational Thromboelastometry–Guided Transfusion Protocols: Analysis of the HEROES-CS (HEmostasis Registry…

Abstract Objectives Rotational  (ROTEM)-guided transfusion algorithms in cardiac surgery have been proven to be successful in reducing blood loss in randomized controlled trials. Using an institutional  registry of patients in cardiac surgery..

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Validation of a Norwegian version of SURgical PAtient Safety System (SURPASS) in combination with the World Health Organizations’ Surgical Safety…

Abstract Introduction Surgical safety checklists may contribute to reduction of complications and mortality. The WHO’s Surgical Safety Checklist (WHO SSC) could prevent incidents in operating theatres, but errors also occur before..

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CNS Complications in Adult Patients Treated With Extracorporeal Membrane Oxygenation

Abstract Objectives To describe the incidence and outcomes of radiologically confirmed acute CNS complications in extracorporeal membrane oxygenation patients at an Australian extracorporeal membrane oxygenation referral center and identify associated..

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Effects of Implementing Rotational Thromboelastometry in Cardiac Surgery: A Retrospective Cohort Study

Abstract Since 2013, rotational thromboelastometry has been available in our hospital to assess coagulopathy. The aim of the study was to retrospectively evaluate the effect of thromboelastometry testing in cardiac..

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Switching to Centrifugal Pumps May Decrease Hemolysis Rates Among Pediatric ECMO Patients

Abstract Recent advances in ECLS technology have led to the adoption of centrifugal pumps for the majority of patients worldwide. Despite several advantages of centrifugal pumps, they remain controversial because..

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Membrane Lung and Blood Pump Use During Prolonged Extracorporeal Membrane Oxygenation

Trends From 2002 to 2017 Extracorporeal life support (ECLS) has grown in its application since its first clinical description in the 1970s. The technology has been used to support a..

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Most Deaths in Low-Risk Cardiac Surgery Could Be Avoidable

Abstract It is observed that death rates in cardiac surgery has decreased, however, root causes that behave like triggers of potentially avoidable deaths (AD), especially in low-risk patients (less bias)..

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Endothelial Function in Patients With von Willebrand Disease

Abstract In patients with von Willebrand disease (vWD) the interest in age-related comorbidities has grown, because the life expectancy of these patients has increased. The research question of this study..

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Mycobacterium Chimaera in Heater-Cooler Devices: An Experience in A Tertiary Hospital in Spain

Abstract The aim of the study was to describe the Mycobacterium chimaera contamination in heater–cooler devices after the application of a protocol of cleaning and disinfection in a tertiary hospital. It was..

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The Minnesota mobile extracorporeal cardiopulmonary resuscitation consortium for treatment of out-of-hospital refractory ventricular fibrillation: Program description, performance, and outcomes

Abstract Background We describe implementation, evaluate performance, and report outcomes from the first program serving an entire metropolitan area designed to rapidly deliver extracorporeal membrane oxygenation (ECMO)-facilitated resuscitation to patients..

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Practical Clinical Application of an Extracorporeal Carbon Dioxide Removal System in Acute Respiratory Distress Syndrome and Acute on Chronic Respiratory…

Abstract We retrospectively reviewed the medical records of 11 patients supported with a veno-venous low-flow extracorporeal carbon dioxide (CO2) removal (ECCO2R) device featuring a large gas exchange surface membrane lung..

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Hematologic Evaluation of Intraoperative Autologous Blood Collection and Allogeneic Transfusion in Cardiac Surgery

Abstract Background Acute normovolemic hemodilution is recommended as a technique to reduce allogeneic red blood cell (RBC) transfusions in cardiac surgery, but its efficacy to reduce non‐RBC transfusion has not..

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In vitro head-to-head comparison of anticoagulation properties of two heparin brands in a human blood miniature mock loop

Abstract OBJECTIVES The first aim was the development of a human blood miniature mock-loop system consisting of 2 identical extracorporeal circuits, which enable systematic head-to-head comparisons of test substances. In..

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Left Ventricular Unloading During Veno-Arterial ECMO: A Simulation Study

Abstract Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is widely used in cardiogenic shock. It provides systemic perfusion, but left ventricular (LV) unloading is suboptimal. Using a closed-loop, real-time computer model..

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Impaired right ventricular ejection fraction after cardiac surgery is associated with a complicated ICU stay

Abstract Background Right ventricular (RV) dysfunction is a known risk factor for increased mortality in cardiac surgery. However, the association between RV performance and ICU morbidity is largely unknown. Methods..

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People, systems and safety: resilience and excellence in healthcare practice

Abstract This article outlines recent developments in safety science. It describes the progression of three ‘ages’ of safety, namely the ‘age of technology’, the ‘age of human factors’ and the..

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The cardiopulmonary bypass and cancer dissemination puzzle

Abstract Early cancer diagnosis, new therapies that increased survival of patients, besides the increasingly elderly population are some factors would be associated with possible cancer dissemination in patients under cardiopulmonary..

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Incidence and risk factors for potentially suboptimal serum concentrations of vancomycin during cardiac surgery

Abstract AIM To investigate the incidence and risk factors for vancomycin concentrations less than 10 mg/L during cardiac surgery. METHODS In this prospective study, patients undergoing cardiac surgery received a..

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Q-PULS, a new quasi-physiological pulsatile extracorporeal model to simulate heart function

Abstract OBJECTIVES The invention of new surgical procedures requires testing at different stages including animal models. To facilitate this process, we have developed a computer-controlled extracorporeal circulation system for testing..

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Comparison of temporary ventricular assist devices and extracorporeal life support in post-cardiotomy cardiogenic shock

Abstract OBJECTIVES Post-cardiotomy cardiogenic shock (PCCS) results in substantial morbidity and mortality, whereas refractory cases require mechanical circulatory support (MCS). The aim of the study was to compare extracorporeal membrane..

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Novel method for estimating the total blood volume: the importance of adjustment using the ideal body weight and age for…

Abstract OBJECTIVES Although total blood volume (TBV) is central to the estimation of the haemodilution rate during cardiopulmonary bypass (CPB), conventional formulas lack sufficient accuracy. The aim of this study..

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Transient acute kidney injury after cardiac surgery does not independently affect postoperative outcomes

Abstract Background The objective of this study was to assess the incidence of in‐hospital acute kidney injury (AKI) after cardiac surgery by comparing preoperative baseline renal function with renal function..

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Protecting the Value of Medical Science in the Age of Social Media and “Fake News”

Abstract New threats to effective scientific communication make it more difficult to separate science from science fiction. Patients can be harmed by misinformation or by misplaced trust; for example, patients..

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Anaphylaxis to intravenous gelatin‐based solutions: a case series examining clinical features and severity

Abstract The proportion of patients receiving intravenous gelatin‐based colloids has increased in the last decade due to safety concerns about starch‐based products. Recent research suggests hypersensitivity reactions to intravenous gelatin‐based..

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Workplace bullying and workplace violence as risk factors for cardiovascular disease: a multi-cohort study

Abstract Aims To assess the associations between bullying and violence at work and cardiovascular disease (CVD). Methods and results Participants were 79 201 working men and women, aged 18–65 years and free..

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