Perfusfind S.L.
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Impact of MELD score and cardiopulmonary bypass duration on post-operative hypoxic hepatitis in patients with liver cirrhosis undergoing open heart…

Abstract Background The outcome of open-heart surgery for patients with liver cirrhosis (LC) varies widely, indicating multifactorial influences on liver injury after cardiopulmonary bypass (CPB). Methods This observational single center..

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Procalcitonin to stop antibiotics after cardiovascular surgery in a pediatric intensive care unit—The PROSACAB study

Abstract Introduction and objective Children admitted to the pediatric intensive care unit after cardiovascular surgery usually require treatment with antibiotics due to suspicion of infection. The aim of this study..

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Effect of cardiac arrest with aortic cross-clamping during left ventricular assist device implantation

Abstract OBJECTIVES Some patients who undergo continuous-flow left ventricular assist device (CF-LVAD) implantation require concomitant procedures that can be performed with or without cardiac arrest under aortic cross-clamping (AXC). Procedures..

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Cartridge-Based Thromboelastography Can Be Used to Monitor and Quantify the Activity of Unfractionated and Low-Molecular-Weight Heparins

Abstract Thromboelastography is increasingly utilized in the management of bleeding and thrombotic complications where heparin management remains a cornerstone. This study assessed the feasibility of the cartridge-based TEG® 6s system (Haemonetics..

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How I wean patients from veno-venous extra-corporeal membrane oxygenation

Introduction Identifying patients who are ready for weaning and liberation from veno-venous extracorporeal membrane oxygenation (ECMO) is challenging in clinical practice. Compared to the several trials addressing the safety and..

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Low flow rate alters haemostatic parameters in an ex-vivo extracorporeal membrane oxygenation circuit

Abstract Background Extracorporeal membrane oxygenation (ECMO) is a life-saving modality used to manage cardiopulmonary failure refractory to conventional medical and surgical therapies. Despite advances in ECMO equipment, bleeding and thrombosis..

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Serum lactate poorly predicts central venous oxygen saturation in critically ill patients: a retrospective cohort study

Abstract Background Serum lactate and central venous oxygen saturation (ScvO2) are commonly used and commonly recommended as markers of tissue oxygenation in shock states. Medical literature has both explicitly stated..

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Is blood a necessary component of the perfusate during isolated limb perfusion – a randomized controlled trial

Abstract Background: Isolated limb perfusion (ILP) is a treatment option for malignancies localized to an extremity and is performed by surgical isolation of the limb which is connected to an extracorporeal..

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A 2-year multicenter, observational, prospective, cohort study on extracorporeal CO2 removal in a large metropolis area

Abstract Background Extracorporeal carbon dioxide removal (ECCO2R) is a promising technique for the management of acute respiratory failure, but with a limited level of evidence to support its use outside..

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Multidisciplinary transcatheter aortic valve replacement heart team programme improves mortality in aortic stenosis

Abstract Objectives To analyse the effect of the implementation of a transcatheter aortic valve replacement (TAVR) and multidisciplinary heart team programme on mortality in severe aortic stenosis (AS). Methods A retrospective, observational..

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Extracorporeal gas exchange: when to start and how to end?

Introduction In the last decade, primarily following the H1N1 pandemics [], the extracorporeal respiratory assist is increasingly used [, ]. The acronym “ECMO”, i.e., ExtraCorporeal Membrane Oxygenation, is, however, somehow misleading..

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Tranexamic acid and convulsive seizures after off-pump coronary artery bypass surgery: the role of renal insufficiency

Abstract There is evidence that, in adult cardiac surgical patients undergoing on-pump procedures, tranexamic acid (TXA) dose-dependently increases the risk of convulsive seizure (CS). We aimed to investigate whether a..

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Perioperative Factors Associated With Changes in Troponin T During Coronary Artery Bypass Grafting

Abstract Objective Investigate important clinical and operative variables associated with increases in cardiac troponin T (cTnT) as indicators of myocardial injury after coronary artery bypass grafting (CABG). Design Prospective cohort..

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Systematic review to assess the possibility of return of cerebral and cardiac activity after normothermic regional perfusion for donors after…

Abstract Background Normothermic regional perfusion (NRP) is a novel technique that aids organ recovery from donors after circulatory death (DCDs). However, ethical concerns exist regarding the potential return of spontaneous..

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Designing an Extracorporeal Cardiopulmonary Resuscitation Protocol: It Is Time to Address Quality

Abstract Extracorporeal cardiopulmonary resuscitation (ECPR) refers to the use of temporary mechanical support as an adjunct to standard CPR in patients with cardiovascular collapse. Although it is a relatively recent..

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Comparative spallation performance of silicone versus Tygon extracorporeal circulation tubing

Abstract OBJECTIVES Reports ranged from mixed to marginal tubing wear and spallation effects as a complication of roller pumps in cardiopulmonary bypass (CPB). Because the rollers constantly compress part of..

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Insight into ECMO, mortality and ARDS: a nationwide analysis of 45,647 ECMO runs

Abstract Background Extracorporeal life support (ECLS) has become an integral part of modern intensive therapy. The choice of support mode depends largely on the indication. Patients with respiratory failure are..

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Merits of and Technical Tips for Supra-Mesenteric Aortic Cross Clamping

Abstract Supra-celiac aortic cross clamping is often utilized during aortic reconstruction for aneurysmal/occlusive disease involving the pararenal aorta. However, this may be accompanied a myriad of complications related to hemodynamic..

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Assessing Computational Model Credibility Using a Risk-Based Framework: Application to Hemolysis in Centrifugal Blood Pumps

Abstract Medical device manufacturers using computational modeling to support their device designs have traditionally been guided by internally developed modeling best practices. A lack of consensus on the evidentiary bar..

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Editorial: Improving Extracorporeal Life Support Outcomes in Children

Abstract Extracorporeal life support (ECLS, also known as extracorporeal membrane oxygenation or ECMO) emerged in the 1970s as a potentially useful life-support therapy for refractory cardiac or respiratory failure in..

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Right atrial pressure and venous return during cardiopulmonary bypass

Abstract The relevance of right atrial pressure (RAP) as the backpressure for venous return (QVR) and mean systemic filling pressure as upstream pressure is controversial during dynamic changes of circulation...

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Identification of mesothelial cells in intraoperative blood salvage

Abstract Intraoperative auto-transfusion with the use of cell saver systems is routinely used to reduce the rate of packed red blood transfusion in major surgery. Nevertheless some concerns have been..

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Evidence-based practice education for healthcare professions: an expert view

Introduction To highlight and advance clinical effectiveness and evidence-based practice (EBP) agendas, the Institute of Medicine set a goal that by 2020, 90% of clinical decisions will be supported by..

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The correlation of post-operative acute kidney injury and perioperative anaemia in patients undergoing cardiac surgery with cardiopulmonary bypass

Abstract Background and objective Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) is polyethiological clinical syndrome. During CPB haemodilution develops, which is useful in reducing the risk..

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The use of mannitol in cardiopulmonary bypass prime solution—Prospective randomized double‐blind clinical trial

Abstract Background The optimal prime solution for the cardiopulmonary bypass (CPB) circuit in adult cardiac surgery has not yet been defined. Mannitol is widely used in the priming solution for..

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Effects of pulsatile minimal invasive extracorporeal circulation on fibrinolysis and organ protection in adult cardiac surgery—a prospective randomized trial

Abstract Background  Minimal invasive extracorporeal circulation (MiECC) reduces the impact of cardiopulmonary bypass during cardiac surgery on inflammation and hemostasis. Pulsatile perfusion may enhance organ perfusion and help to prevent..

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Inflammation and coagulation following minimally invasive extracorporeal circulation technologies

Abstract Minimally invasive extracorporeal perfusion technologies are based on the use of a minimally invasive extracorporeal circulation (MiECC) system. This includes a closed CPB circuit; biologically inert blood contact surfaces;..

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Monitoring and optimization of the microcirculation during CPB

Abstract  In this review the impact of cardiopulmonary bypass (CPB) on the microcirculation is discussed. The impact of conventional non-pulsatile perfusion is contrasted with the microcirculatory impact of pulsatile CPB..

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Microcirculatory perfusion disturbances following cardiac surgery with cardiopulmonary bypass are associated with in vitro endothelial hyperpermeability and increased angiopoietin-2 levels

Abstract Background Endothelial hyperpermeability following cardiopulmonary bypass (CPB) contributes to microcirculatory perfusion disturbances and postoperative complications after cardiac surgery. We investigated the postoperative course of renal and pulmonary endothelial barrier..

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Neuromonitoring in the neonatal ECMO patient

Abstract Utilization of extraocorporeal membrane oxygenation (ECMO) has become increasingly widespread as a bridging therapy for neonates with severe, reversible respiratory or cardiac diseases. While significant risks remain, due to..

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