Perfusfind S.L.
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Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale

Abstract In order to assess mechanisms underlying inflammatory activation during extracorporeal circulation (ECC), several small animal models of ECC have been proposed recently. The majority of them are based on..

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High central venous saturation after cardiac surgery is associated with increased organ failure and long-term mortality: an observational cross-sectional study

Abstract Introduction Central venous saturation (ScvO2) monitoring has been suggested to address the issue of adequate cardiocirculatory function in the context of cardiac surgery. The aim of this study was..

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Randomized, Double‐Blinded, Placebo‐Controlled Trial of Fibrinogen Concentrate Supplementation After Complex Cardiac Surgery

Abstract Background Postoperative bleeding after heart operations is still a common finding, leading to allogeneic blood products transfusion. Fibrinogen and coagulation factors deficiency are possible determinants of bleeding. The experimental..

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Veno-venous extracorporeal CO2 removal for the treatment of severe respiratory acidosis: pathophysiological and technical considerations

Abstract Introduction While non-invasive ventilation aimed at avoiding intubation has become the modality of choice to treat mild to moderate acute respiratory acidosis, many severely acidotic patients (pH <7.20) still..

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Lower limb overflow syndrome in extracorporeal membrane oxygenation

Abstract Peripheral extracorporeal membrane oxygenation (ECMO) is associated with a not negligible rate of vascular morbidity. Most vascular complications are related to limb ischaemia mainly due to insufficient limb perfusion..

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Is it possible to predict the risk of ischaemic bowel after cardiac surgery?

Abstract A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was ‘Is it possible to predict the risk of ischaemic bowel after..

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Do patients with haematological malignancy who need cardiopulmonary bypass have a short-term higher mortality or a higher chance of disease…

Abstract A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether patients with haematological malignancy (HM) who need cardiopulmonary bypass (CPB)..

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Size Distribution of Air Bubbles Entering the Brain during Cardiac Surgery

Abstract Background Thousands of air bubbles enter the cerebral circulation during cardiac surgery, but whether high numbers of bubbles explain post-operative cognitive decline is currently controversial. This study estimates the..

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Bypass during Liver Transplantation: Anachronism or Revival? Liver Transplantation Using a Combined Venovenous/Portal Venous Bypass—Experiences with 163 Liver Transplants in…

Abstract Introduction. The venovenous/portal venous (VVP) bypass technique has generally become obsolete in liver transplantation (LT) today. We evaluated our experience with 163 consecutive LTs that used a VVP bypass. Patients..

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Impact of closed minimal extracorporeal circulation on microvascular tissue perfusion during surgical aortic valve replacement: intravital imaging in a prospective…

Abstract OBJECTIVES Closed minimal extracorporeal circulation (MECC) systems currently do not represent the standard of surgical care for open-heart surgery. Yet, considering the beneficial results reported for coronary artery bypass..

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Intraoperative change of lactate level is associated with postoperative outcomes in pediatric cardiac surgery patients: retrospective observational study

Abstract Background A change of serum lactate concentrations appeared to be useful for predicting outcomes in various acute ill settings. However, there is little information on intraoperative change of lactate..

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Are the precapillary sphincters and metarterioles universal components of the microcirculation? An historical review

Abstract The microcirculation is a major topic in current physiology textbooks and is frequently explained with schematics including the precapillary sphincters and metarterioles. We re-evaluated the validity and applicability of..

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Effect of Prone Positioning on Intensity of Inspiratory Effort in ARDS

Abstract Patients with acute respiratory distress syndrome (ARDS) who were placed in the prone position had improved gas exchange and reduced intensity of inspiratory effort compared with the supine position,..

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Pharmacokinetic model of unfractionated heparin during and after cardiopulmonary bypass in cardiac surgery

Abstract Background: Unfractionated heparin (UFH) is widely used as a reversible anti-coagulant in cardiopulmonary bypass (CPB). However, the pharmacokinetic characteristics of UFH in CPB surgeries remain unknown because of the..

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Sodium Bicarbonate and Renal Function after Cardiac Surgery: A Prospectively Planned Individual Patient Meta-analysis

Abstract Background: The effect of urinary alkalinization in cardiac surgery patients at risk of acute kidney injury (AKI) is controversial and trial findings conflicting. Accordingly, the authors performed a prospectively..

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Intraoperative Core Temperature Patterns, Transfusion Requirement, and Hospital Duration in Patients Warmed with Forced Air

Abstract Background: Core temperature patterns in patients warmed with forced air remain poorly characterized. Also unknown is the extent to which transient and mild intraoperative hypothermia contributes to adverse outcomes..

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Troubleshooting during a challenging high-risk pacemaker lead extraction: a case report and review of the literature

Abstract Background The use of cardiac implantable electrical devices continues to increase with the validation of new beneficial indications. While the risks of device implantation decreased significantly over time, significant..

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Comparison of Anticoagulation Strategies in Patients Requiring Venovenous Extracorporeal Membrane Oxygenation

Abstract Objectives:  Extracorporeal membrane oxygenation is a life-sustaining therapy for severe respiratory failure. Extracorporeal membrane oxygenation circuits require systemic anticoagulation that creates a delicate balance between circuit-related thrombosis and bleeding-related..

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Evaluation of cefazolin antimicrobial prophylaxis during cardiac surgery with cardiopulmonary bypass

Abstract Objectives Although clinical practice guidelines recommend standard cefazolin antimicrobial prophylaxis (AP) dosing for cardiac surgery, limited data exist as to whether adequate concentrations are achieved in this patient population...

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Lung transplantation for idiopathic pulmonary arterial hypertension on intraoperative and postoperatively prolonged extracorporeal membrane oxygenation provides optimally controlled reperfusion and…

Abstract OBJECTIVES Lung transplantation for idiopathic pulmonary arterial hypertension has the highest reported postoperative mortality of all indications. Reasons lie in the complexity of treatment of these patients and the..

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Increased Inflammation in Pericardial Fluid Persists 48 Hours After Cardiac Surgery

Abstract Cardiac surgery causes direct trauma to cardiac tissue, breaches the pericardium, and disrupts the normal composition of the fluid largely produced from the myocardial interstitium and epicardial and visceral..

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Initial ELSO Guidance Document: ECMO for COVID-19 Patients with Severe Cardiopulmonary Failure

The Extracorporeal Life Support Organization (ELSO) and all of the ELSO worldwide chapters have prepared this document to describe when and how to use extracorporeal membrane oxygenation (ECMO) in COVID-19..

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Extracorporeal Life Support Organization (ELSO): 2020 Pediatric Respiratory ELSO Guideline

Extracorporeal membrane oxygenation (ECMO) should be considered in patients in whom a reversible pathology is known or suspected, and in whom providing ECMO poses less risks than not providing extracorporeal..

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Extracorporeal Life Support Organization (ELSO): Guidelines for Neonatal Respiratory Failure

This guideline describes prolonged extracorporeal life support (ECLS), applicable to newborn infants with respiratory failure. These guidelines address technology and patient management during ECMO. Equally important issues such as personnel,..

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Extracorporeal Membrane Oxygenation and Extracorporeal Cardiopulmonary Resuscitation for a COVID-19 Pediatric Patient: A Successful Outcome

Pediatric population have been affected by the Coronavirus disease 2019 (COVID-19) to a much smaller scale compared with the adult population. The severity of the disease is variable ranging from..

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ECMO for COVID-19 Updated 2021 Guidelines from the Extracorporeal Life Support Organization (ELSO)

This is an updated guideline from the Extracorporeal Life Support Organization (ELSO) for the role of extracorporeal membrane oxygenation (ECMO) for patients with severe cardiopulmonary failure due to coronavirus disease..

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Pediatric Extracorporeal Cardiopulmonary Resuscitation ELSO Guidelines

Why Consider ECPR for Cardiopulmonary Arrest in Children? Because Conventional CPR may not be Sufficient to Optimize Outcomes in all Pediatric Cardiopulmonary Arrests Situations Survival rates with good neurologic outcomes..

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Venous Cannulation for Cardiopulmonary Bypass in the Case of Anomaly of the Inferior Vena Cava

Abstract  of the  and its tributaries are quite uncommon; however, since the development of , they have been described more frequently. Most of them are usually asymptomatic, although they can have clinical..

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Maternal obesity and excessive maternal weight gain during pregnancy: effects on outcomes after neonatal cardiac surgical procedures

Abstract Introduction Maternal obesity is associated with an increased risk for adverse perinatal outcomes. Obesity is also associated with a chronic inflammatory state and metabolic derangements that affect the newborn...

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Is therapeutic hypothermia during neonatal extracorporeal membrane oxygenation associated with intracranial hemorrhage?

Abstract Introduction: The use of therapeutic hypothermia during neonatal extracorporeal membrane oxygenation (ECMO) as a neurologic protective strategy has gained interest among clinicians despite limited data. Our objective is to..

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