Introduction: Cardiopulmonary bypass (CPB) is a vital component of many cardiac surgeries, but it can trigger systemic inflammatory responses, leading to post-operative complications. The CytoSorb filter, a cytokine adsorber, has emerged as a potential adjunctive therapy in CPB to mitigate inflammation.

Method: A literature review was conducted to assess the impact of CytoSorb on inflammation and clinical outcomes during cardiac surgery with CPB. Various databases were searched including PubMed, MEDLINE, and Google Scholar using relevant keywords.

Results: Studies have shown mixed results regarding CytoSorb’s efficacy in reducing pro-inflammatory cytokines and improving clinical outcomes. Some studies reported reduced cytokine levels, improved hemodynamics, and decreased need for vasopressors. However, others found no significant cytokine reduction or clinical improvement. CytoSorb was generally well-tolerated with no device-related serious adverse events reported. Additionally, CytoSorb demonstrated potential benefits in reducing bleeding complications when used in patients taking antiplatelet or anticoagulant medications during cardiac surgery.

Discussion: The use of CytoSorb in cardiac surgery with CPB holds promise but requires further research. Future directions include evaluating long-term benefits and safety, refining patient selection criteria, conducting comparative studies, standardizing guidelines for CytoSorb integration, and exploring its utility in other cardiac surgery scenarios.

Conclusion: CytoSorb offers potential benefits in attenuating systemic inflammation during cardiac surgery with CPB. While evidence suggests positive outcomes in specific contexts, more research is needed to establish its regular use and optimize patient care. Collaborative decision-making and individualized patient management are essential when considering CytoSorb therapy. Continued investigation will provide valuable insights into its precise role in managing inflammation during CPB, enhancing patient outcomes, and refining clinical protocols.