{"id":501,"date":"2025-01-23T11:30:38","date_gmt":"2025-01-23T11:30:38","guid":{"rendered":"https:\/\/perfusfind.com\/ic\/?p=501"},"modified":"2025-01-23T11:30:52","modified_gmt":"2025-01-23T11:30:52","slug":"effect-of-emodin-on-acute-lung-injury-a-meta-analysis-of-preclinical-trials","status":"publish","type":"post","link":"https:\/\/perfusfind.com\/ic\/index.php\/2025\/01\/23\/effect-of-emodin-on-acute-lung-injury-a-meta-analysis-of-preclinical-trials\/","title":{"rendered":"Effect of emodin on acute lung injury: a meta-analysis of preclinical trials"},"content":{"rendered":"

Abstract<\/h2>\n
\n

Background<\/h3>\n

Emodin has protective effects on acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). This meta-analysis intended to illustrate the efficacy of emodin on ALI\/ARDS animal models.<\/p>\n

Methods<\/h3>\n

Relevant preclinical studies were searched on PubMed, EMBASE, and Web of Science. Standardized mean differences (SMDs) with corresponding confidence intervals (CIs) were used to compare lung injury scores, lung wet-to-dry weight ratios (W\/D), myeloperoxidase (MPO), tumor necrosis factor-\u03b1 (TNF-\u03b1), interleukin-1\u03b2 (IL-1\u03b2), IL-6, IL-18, PaO2<\/sub>, and PaCO2<\/sub>\u00a0between the treatment and control groups. The article quality was appraised using the SYRCLE tool.<\/p>\n

Results<\/h3>\n

Twenty one studies published between 2014 and 2023 were enrolled. Compared with the control group, emodin significantly reduced lung injury scores (SMD: -3.63; 95% CI: -4.36, -2.90;\u00a0p<\/i>\u2009<\u20090.00001), W\/D ratios (SMD: -3.23; 95% CI: -4.29, -2.16;\u00a0p<\/i>\u2009<\u20090.00001), and MPO levels (SMD: -2.96; 95% CI: -3.92, -1.99;\u00a0p<\/i>\u2009<\u20090.00001). Furthermore, emodin downregulated TNF-\u03b1 (SMD: -3.04; 95% CI: -3.62, -2.47;\u00a0p<\/i>\u2009<\u20090.00001), IL-1\u03b2 (SMD: -3.76; 95% CI: -4.65, -2.87;\u00a0p<\/i>\u2009<\u20090.00001), IL-6 (SMD: -3.19; 95% CI: -3.95, -2.43;\u00a0p<\/i>\u2009<\u20090.00001), and IL-18 levels (SMD: -4.83; 95% CI: -6.10, -3.57;\u00a0p<\/i>\u2009<\u20090.00001). Emodin improved gas exchange dysfunction, increased PaO2<\/sub>\u00a0(SMD: 3.76; 95% CI: 2.41, 5.11;\u00a0p<\/i>\u2009<\u20090.00001), and decreased PaCO2<\/sub>\u00a0(SMD: -3.83; 95% CI: -4.90, -2.76;\u00a0p<\/i>\u2009<\u20090.00001). Sensitivity analyses and stratified analyses were conducted for outcome measures with heterogeneity.<\/p>\n

Conclusions<\/h3>\n

Emodin treatment can effectively reduce the severity of ALI in animal models. Additional animal investigations and clinical trials involving human subjects are imperative.<\/p>\n

Key Points<\/strong>:<\/p><\/blockquote>\n

    \n
  1. Emodin’s Mechanism of Action<\/strong>: Reduces inflammation, oxidative stress, and neutrophil accumulation, alleviating ALI pathophysiology.<\/li>\n
  2. Reduction in Inflammatory Markers<\/strong>: Downregulates TNF-\u03b1, IL-1\u03b2, IL-6, and IL-18, mitigating inflammatory responses that exacerbate ALI.<\/li>\n
  3. Improved Gas Exchange<\/strong>: Enhances oxygenation (PaO2) and reduces hypercapnia (PaCO2), addressing respiratory dysfunction in ALI.<\/li>\n
  4. Preclinical Evidence<\/strong>: Analysis of 21 studies shows consistent improvements in lung injury scores and pulmonary edema markers like wet-to-dry ratios (W\/D).<\/li>\n
  5. Therapeutic Dose Range<\/strong>: Effective at doses between 10-700 mg\/kg with both preventive and post-ALI treatments showing efficacy.<\/li>\n
  6. Variability in Models<\/strong>: Effects were robust across various ALI models, including lipopolysaccharide-induced and ischemia-reperfusion injury.<\/li>\n
  7. Safety Profile<\/strong>: Animal studies report no significant adverse effects, supporting emodin’s potential translational viability.<\/li>\n
  8. Potential as an Adjunctive Therapy<\/strong>: Could complement existing treatments by targeting inflammatory pathways and promoting alveolar stability.<\/li>\n
  9. Research Gaps<\/strong>: High heterogeneity in study designs necessitates standardization for future preclinical and clinical research.<\/li>\n
  10. Clinical Relevance<\/strong>: Highlights the need for clinical trials to explore emodin’s safety and efficacy in treating human ALI\/ARDS.<\/li>\n<\/ol>\n

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