Sepsis is a dysregulated host response to infection responsible for life-threatening organ dysfunction.¹  Along with early antimicrobial administration and source control, correction of hemodynamic derangements is a crucial aspect of sepsis management. In this review, we will discuss the recent evidence in managing sepsis-induced hemodynamic alterations and how it can be integrated with previous knowledge for actionable interventions in adult patients. Fluid underresuscitation is associated with a risk of poor organ perfusion and excessive vasopressors use, while overresuscitation is associated with a risk of fluid overload and organ congestion (i.e., pulmonary edema, abdominal compartment syndrome, acute kidney injury [AKI], liver injury). In this review, we will especially discuss the strategies for initial fluid resuscitation and vasopressors administration, the choice of fluid, and hemodynamic targets to guide resuscitation in adults.